2083 Background: Second-line treatment in recurrent or progressive glioblastoma (GBM) has not yet been defined. Since in vitro and preclinical studies demonstrated a hyper-radiosensitivity of human malignant glioma cell lines to low doses fractionated radiotherapy (LD-FRT) and a synergism with chemotherapy, we performed a pilot study to evaluate the feasibility and efficacy of this approach. ...

psychotic disorders and bipolar disorder (8) and between bipolar disorder and major depressive disorder (9). Although family and twin studies can estimate the shared heritability across disorders, they cannot identify the genetic loci contributing to this overlap. To date, evidence implicating specifi c chromosomal regions and genes in the shared liability to psychotic and mood disorders has la...

MANY common disorders, including schizophrenia ers are affected, however, and the probable mode of disease inheritance is dominant with reduced peneand bipolar affective disorder, are highly heritatrance. That is to say inheritance of the translocation ble, yet do not exhibit simple inheritance patterns. Indiconfers a genetic predisposition to develop psychiatric vidual risk is usually attribut...

in economic and competitive environments and their effects on observed to model multi-attribute model consumer decisions sales levels. Because in general micro-level data on strategic decision (for reviews, see Green and Srinivasan, 1978, 1990; Louviere, making over time are difficult and expensive to obtain, this approach can 1988, 1994), also can be applied to model how managers are be of muc...

Arterial hypertension is a complex trait caused by many environmental and genetic factors playing together and in interaction. This complexity has limited the identification of susceptibility genes for this major cardiovascular risk factor to controversial loci and candidate genes.1 Conversely, search for major genes implicated in rare Mendelian forms of the disease has been particularly succes...

In this Journal we previously reported the predicted SARS-CoV-2 spike-host cell receptor GRP78 binding site (1Ibrahim I.M. Abdelmalek D.H. Elshahat M.E. Elfiky A.A. COVID-19 prediction.J Infect. 2020; 80: 554-562Abstract Full Text PDF PubMed Scopus (343) Google Scholar). New variant VUI 202,012/01 started in UK and currently spreading Europe Australia during last few days. The new bears about n...

This article studies the spatial dimension of social selection local elected officials that takes shape through geographical selectivity officials’ places residence. Based on data residence in Zurich and Lausanne (1980-2016), we show residential dispersion is not random but driven by a logic class socio-spatial selectivity. We also this varies according to partisan affiliation existence or elec...