Cancer is the uncontrolled growth and spread of cells. It can affect any part of the body. The growths often invade surrounding tissue and can metastasize to distant sites [1]. Majority of the cancer (90%-95%) are caused by frequent use of tobacco, obesity or over weight, chronic infections and prolonged exposure to radiations and a notable percentage (5%-10%) are due to heredity. Most cancer c...

In an attempt to explore a new class of epidermal growth factor receptor (EGFR) inhibitors, novel 4-stilbenylamino quinazoline derivatives were synthesized through a Dimorth rearrangement reaction and characterized via IR, ¹H-NMR, 13C-NMR, and HRMS. Methoxyl, methyl, halogen, and trifluoromethyl groups on stilbeneamino were detected. These synthesized compounds were evaluated for antitumor acti...

A highly efficient and versatile synthetic approach to the synthesis of annelated quinazoline derivatives viz. 3,4,9,10a-tetraazaphenanthrenes 5 – 7, thiazolidinylquinazoline 9, 2,4,9,10a-tetraazaphenanthrene 11, quinazolino[4,3-b]quinazolin-8-one 12 and imidazoquinazolines 14a,b, 15. Also, a variety of pyrazolylquinazolines 19 – 21, pyrimidinylquinazolines 22a,b were obtained via a sequence of...

quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. due to valuable cytotoxic effects of both thiazole gr...

We describe in this paper the synthesis of a novel series anilino-2-quinazoline derivatives. These compounds have been screened against panel eight mammalian kinases and parallel they were tested for cytotoxicity on representative seven cancer cell lines. One them (DB18) has found to be very potent inhibitor human “CDC2-like kinases” CLK1, CLK2 CLK4, with IC50 values 10–30 nM range. Interesting...

This research. Included the preparation. and characterization some novel. Six seven membered Heterocyclic. Compounds ( oxazepine , thiazine quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). second (1) 4 -hydroxy schiff (2) last involve Phthalic Maleic Succinic) anhydride .get derivatives (3,4and 5) also with...

The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic a...

Twenty-two quinazoline derivatives have been synthesised and examined for their anti-tumour activity against three tumour cell lines, namely human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human hepatoma cell line (HepG2). Twelve of the tested compounds have shown promising anti-tumour activity with an IC(50) range of 5.0-9.7 µg/mL. Regarding the spectrum of ac...