The oxidative metabolism of irbesartan, a new nonpeptide angiotensin II receptor antagonist, was investigated on 12 human fully characterized hepatic microsomes and purified cytochrome P-450 (CYP) isoforms. After incubation of microsomes with irbesartan and NADPH, four main hydroxy metabolites were formed, as confirmed by liquid chromatography-mass spectrometry analysis. Irbesartan oxidation fo...

This review focuses on key components of respiratory and photosynthetic energy-transduction systems: the cytochrome bc1 b6f (Cytbc1/b6f) membranous multisubunit homodimeric complexes. These remarkable molecular machines catalyze electron transfer from quinones to water-soluble carriers (such as cytochromes c or plastocyanin), coupling flow proton translocation across energy-transducing membrane...

The striking resemblance of the rhombohedral and monoclinic forms of the title molecule to beta- and gamma-quinol provides a crystal engineering approach to new polymorphic systems.

Toluene dioxygenase-catalysed cis-dihydroxylation of phenols has led to the discovery of new enantiopure cyclohexenone cis-diol, o-quinol dimer and phenol hydrate metabolites having synthetic potential.

The title compound, [Cu(2)(C(11)H(8)NO(3))(2)Cl(2)], is a bicopper(II) complex. Each Cu(II) ion is five-coordinated by two O atoms and one N atom from the (8-quinol-yloxy)acetate ligand, and by two μ(2)-chloride ligands, thus exhibiting a distorted square-pyramidal CuCl(2)NO(2) coordination environment. Each (8-quinol-yloxy)acetate anion acts as a tridentate chelating ligand. In the crystal str...

Native structures of ubihydroquinone:cytochrome c oxidoreductase (bc(1) complex) from different sources, and structures with inhibitors in place, show a 16-22 A displacement of the [2Fe-2S] cluster and the position of the C-terminal extrinsic domain of the iron sulfur protein. None of the structures shows a static configuration that would allow catalysis of all partial reactions of quinol oxida...