A straightforward synthesis of substituted quinolines is described by cyclocondensation of anilines with 1,3-diols. The reaction proceeds in mesitylene solution with catalytic amounts of RuCl(3)·xH(2)O, PBu(3) and MgBr(2)·OEt(2). The transformation does not require any stoichiometric additives and only produces water and dihydrogen as byproducts. Anilines containing methyl, methoxy and chloro s...

Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

new series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. in this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. the inhibitory activities of synthesized compounds were tested against ja...

triphenyl phosphine(pph3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4h-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in etoh-h2o (1:1) at reflux conditions. the results show that aromatic aldehydes containing electron-donating groups or electron-withdrawing groups cou...

The title compound, C(9)H(9)ClN(2)O(5)S, is of inter-est as a precursor to biologically active substituted quinolines and related compounds. The structure displays inter-molecular C-H⋯O inter-actions. Each mol-ecule is linked to two adjacent neighbours via weak centrosymmetric dimer-forming inter-actions, forming chains in the [101] direction.

A novel strategy has been identified for the regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from simple alkenes via anti-Markovnikov selectivity under palladium catalysis. The salient features are synthesis of two different heterocycles, readily available starting materials, broad substrate scope, moderate to good yields and use of molecular oxygen as...

in this research we used heavy propylene tetramer (hpt) and a1c13 —bf3 (lewis acids) ascatalyst and ethanol, n-propanol and n-butanol as co-catalyst. using lewis acids as catalyst, thehpts form molecules with higher molecular weight. since the raw materials of the reaction are byproducts of other reactions, are not pure and contain various compounds with different m.w andalso different chemical...

The utilization of green chemistry techniques is dramatically reducing chemical waste and reaction times as has recently been proven in several organic syntheses and chemical transformations. To illustrate these advantages in the synthesis of bioactive heterocycles, we have studied various environmentally benign protocols that involve greener alternatives. Microwave (MW) irradiation of neat rea...

Ruthenium complexes are remarkable catalysts for the C–H activation approaches and organic transformations. Combining a Ru-catalyst with oxidants other additives in one-pot process is considered sustainable approach due to reduction reaction steps minimal usage of solvents during synthesis, work-up, isolation chemicals, purification products. This review highlights ruthenium-catalyzed transform...