introduction: the aim of this in vitro study was to compare the efficacy of protaper retreatment (protaper r) and mtwo retreatment (mtwo r) files in removing gutta-percha and guttaflow from endodontically treated straight root canals. methods and materials: the root canals of 60 human mandibular single-rooted premolars were prepared and randomly divided into two groups ( n =30). in groups a and...

The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics. Focusing on protein 1BBL, a candidate for downhill folding behavior, and comparing it to the WW domain of protein PIN1, a two-state folder of comparable size, the authors show tha...

From April 2005 all doctors in the UK will be expected to be able to demonstrate their fitness to practice as part of the GMC revalidation procedures. The revalidation process is explicitly linked to the consultant appraisal process implemented in 2001. Central to both processes is the development of a folder (portfolio) of supporting evidence. Many consultants have no experience of developing ...