The immunosuppressive macrolide rapamycin and its derivative everolimus (SDZ RAD, RAD) inhibit the mammalian target of rapamycin (mTOR) signaling pathway. In this study, we provide evidence that RAD has profound antiproliferative activity in vitro and in NOD/SCID mice in vivo against Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) cells. Moreover, we identified 2 molecular mecha...

AIMS Our previous studies documented that Rad (Ras associated with diabetes), a member of the RGK (Rad, Gem, and Kir) family of Ras-related small G protein, is significantly decreased in human failing hearts and plays an important role in attenuating cardiac hypertrophy. The goal of this study is to identify the effect of Rad on cardiac fibrosis and the underlying mechanisms. METHODS AND RESU...

PURPOSE To centrally assess the safety, efficacy, and 6-year follow-up of recombinant adenovirus-p53 (rAd-p53) combined with radiotherapy (RT) for patients with nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS A randomized controlled clinical study on rAd-p53 combined with RT in 42 patients with NPC was compared with a control group of 40 patients with NPC treated with RT alone. In the gr...

Adresa za dopisivanje Theodoros Klironomos Address: Agiou Thoma 4, 11527 Athens, Greece tel.: +30 6978559464 e-adresa: [email protected] Sažetak Svrha ovoga članka bila je sažeti trenutačno znanje o učincima mikrovalne dezinfekcije na svojstva materijala za izradu proteza. Kontrola križne infekcije u dentalnoj medicini itekako je važna u svakodnevnoj kliničkoj praksi jer su u porastu raz...

Adresa za dopisivanje Dr. sc. Ivan Puhar Zavod za parodontologiju Stomatološki fakultet Gundulićeva 5 10000 Zagreb, Hrvatska tel: +38514899219 [email protected] Sažetak Pojam quorum sensing označava međustaničnu komunikaciju bakterija kojom koordiniraju gensku ekspresiju populacije sukladno njezinoj gustoći. Bakterije proizvode i ispuštaju u međustanični prostor male molekule, tzv. autoinduktore, č...