BACKGROUND Vessel injury at the time of Arteriovenous Fistula (AVF) creation may lead to neointimal hyperplasia that impairs AVF maturation. Vonapanitase, a recombinant human chymotrypsin-like elastase family member 1, is an investigational drug under development to improve AVF maturation and patency. The current studies were designed to document vonapanitase effects in human cephalic veins tha...

  Background: Arteriovenous Fistula (AVF)is the ideal method of vascular access for patients on maintenance hemodialysis (HD).Therefore it is an important part of treatment in HD.There are several observations that indicate the role of inflammation in failure of AVF.The aim of this study was to evaluate the hematologic and inflammatory biomarkers in early AVF failure.   Methods : This case-cont...

An enterocutaneous fistula is an abnormal communication between the small or large bowel and the skin, which leads to external drainage of intestinal contents. It is an important issue in surgical practice, as most cases occur secondary to surgical complications and cause significant mortality and morbidity owing to septic complications [1,2]. Postoperative fistulas account for 75%–85% of all e...

Vascular tissue contains abundant elastic fibers that contribute to vessel elasticity. Vonapanitase (formerly PRT-201) is a recombinant human chymotrypsin-like elastase family member 1 (CELA1) shown to cleave the elastin component of elastic fibers, resulting in increased vessel diameter. The purpose of these current studies was to determine vein diameter, wall thickness, elastin content, and v...

OBJECTIVE To measure the effect of columellar struts and cephalic trim on tip projection and tip rotation using digitized photographs. METHODS Using photographs of 62 patients who underwent external rhinoplasty, we retrospectively analyzed nasal tip projection (the Goode method) and rotation (nasolabial angle) before and after surgery. A cartilaginous strut was used in 36 patients, whereas 26...