BACKGROUND AND AIM Atherosclerosis evolves or accelerates when arteries are exposed to ionizing radiation, both early and late after exposure. Radioiodine therapy of benign thyroid disease exposes the carotid arteries to 4-50 Gy, and may thereby increase the risk of atherosclerosis. Increased risk of cerebrovascular events has been reported after radioiodine therapy. This study aimed to examine...

SUMMARY In order to evaluate the long-ter m effects of antithyroids and ahlative therapy on patients with toxic diffuse goiter (TDG) in an iodine deficient region, 206 patients were studied in Tehran. Hyperthyroidism recurred in 50%, of 80 patients treated with Methimazole (MMI), from one week to 48 months after cessation of therapy. Another 40 patients remained in remission. Of 102 patients t...

1. The subcellular particles of horse and rat thyroids were fractionated in a B XIV zonal rotor on a non-linear gradient of Ficoll after labelling with radioactive iodine in vitro (horse) or in vivo (rat). In the horse, the resulting fractions were analysed for radioactive iodine, protein and enzymes representative of certain subcellular particles. In the rat, iodine turnover and thyrotrophin s...

operation. The remaining two rats were unoperated controls. In the second experiment, 96 rats were grouped, 3 days after arrival, so that each cage contained rats of sizes ranging from the smallest to the largest found in the entire lot. Half of the rats in each cage were then implanted with the tumor as before, and the other half were sham-operated to serve as controls for the rats in the adja...

1311 therapy as to the effect on either mortality rates or the underlying pathologic process, worthwhile results have been cited in approximately 75 per cent of the cases treated. Despite the apparent unanimity of opinion on the efficacy of this form of therapy, there is considerable variation in the reports cited in dosage schedules employed and in the mode of assessment of the results of radi...

One of the earliest uses of radioiodine was as a tool for the study of thyroid physiology (1-7). Estimations of the relative quantities of isotope stored in the thyroid have been made by means of a Geiger-Muller tube held over the gland and by determining the amount present in the urine and blood. The rate with which the level of radioiodine changes in these compartments has also been studied (...