Background: Owing to its favourable decay characteristics 177Lu [T1/2= 6.71 d, Eβ(max)= 497 keV] is an attractive radionuclide for various therapeutic applications. Ethylene diamine tatramethylene phosphonate (EDTMP) is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. Materials and Methods: Enriched 176Lu2O3 was dissolve...

Thalidomide is a sedative drug discovered at the end of 50s, it showed high anticancer activity so attempts were made to synthesize thalidomide analogs that had fewer side effects than parent compound. DPDQA higher activities thalidomide. Labeling with 99mTc using Na2S2O4 as reducing agent was performed. The dependence radiolabeling yield on concentrations and agent, pH reaction mixture, time, ...

At least venomous snake bites 2000 persons each year in US. The severity of envenomation depends of the snake specie, its size, location of the bite and quantity of venom injected; but also depends of the health of the victim, age, size, and the time it takes to receive medical care. The envenomation is a medical emergency that requires fast attention to avoiding fatalities; in this sense, know...

Abstract Background Lead-212 ( 212 Pb, t 1/2 = 10.6 h) and lead-203 203 51.9 are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy (TRT) single-photon emission computed tomography (SPECT), respectively. At TRIUMF we have produced both Pb using TRIUMF’s TR13 (13 MeV) 500 MeV cyclotrons, subsequently purifi...

Quantitative drug metabolite profiling is an important application in the pharmaceutical industry. Researchers involved in drug development require an analytical technique with a response that is independent of compound structure. This compound-independent response enables accurate quantification of the drug and its metabolites, without requiring compound-specific calibration. Currently, radiol...

RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. The elucidation of the mechanisms by which these modifications impact cellular processes necessitates the ability to both detect and quantify the presence of these modifications within RNA molecules. Here, we present a detailed procedure that allows the detection and quantification of RNA base ...