نتایج جستجو برای: radioprotective agents

تعداد نتایج: 361447  

Journal: :Indian journal of experimental biology 2000
I P Kumar H C Goel

Aqueous extract of Podophyllum species has been reported to render significant protection against radiation induced mortality, cytogenetic damage and cell death. In view of this, present study was undertaken to investigate its antioxidant properties. Chelation, oxidation and reduction of Fe2+ and Fe3+ were measured using chelating agents 2-2' bipiridyl and potassium thiocyanate respectively. Po...

2014
Elisângela Düsman Alessandra Paim Berti Rosinete Gonçalves Mariucci Nilson Benedito Lopes Lilian Tatiani Düsman Tonin Veronica Elisa Pimenta Vicentini

BACKGROUND The increasing consumption of fruits and vegetables has contributed to the improvement of populational health, due in part, to the abundance of antioxidants in these foods. Antioxidants reduce the level of oxidative damage to DNA caused by free radicals and ionizing radiation, including the radioisotope iodine-131 (131I). This isotope is used for the diagnosis and treatment of thyroi...

Journal: :Arhiv za higijenu rada i toksikologiju 2006
Nevenka Kopjar Slavica Miocić Snjezana Ramić Mirta Milić Tomislav Viculin

Radioprotective effects of amifostine and melatonin as well as their ability to modulate the level of spontaneous and gamma-irradiation-induced genetic changes on human peripheral blood lymphocytes were investigated using the cytokinesis-block micronucleus (CBMN) assay and sister chromatid exchange (SCE). Parallel blood samples were pre-treated with amifostine, melatonin and their combination f...

2013
Yu-xiong Su Geza A. Benedek Peter Sieg Gui-qing Liao Andreas Dendorfer Birgit Meller Dirk Rades Matthias Klinger Samer G. Hakim

BACKGROUND Previously we verified the radioprotective effect of lidocaine on the function and ultrastructure of salivary glands in rabbits. However, the underlying mechanism of lidocaine's radioprotective effect is unknown. We hypothesized that lidocaine, as a membrane stabilization agent, has a protective effect on intracellular neuroreceptor-mediated signaling and hence can help preserve the ...

Journal: :journal of biomedical physics and engineering 0
s rahgoshai department of medical radiation science, school of paramedicine, shahid beheshti university of medical sciences, tehran, iran e-mail: [email protected]. m mohammadi department of medical radiation science, school of paramedicine, shahid beheshti university of medical sciences, tehran, iran e-mail:[email protected] s refahi department of medical physics, faculty of medicine, ardabil university of medical sciences, ardabil, iran. email: [email protected] m oladghaffari cellular & molecular biology research center, medical physics department, faculty of medicine, babol university of medical sciences e-mail: [email protected] s m r aghamiri department of radiation medicine - shahid beheshti university of medical sciences-tehran,iran. email: [email protected]

radiation damage is to a large extent caused by overproduction of reactive oxygen species (ros). radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells. radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the ...

Journal: :The Biochemical journal 2012
Yunhai Chuai Fu Gao Bailong Li Luqian Zhao Liren Qian Fei Cao Lei Wang Xuejun Sun Jianguo Cui Jianming Cai

Our recent studies suggest that H2 (hydrogen) has a potential as a novel radioprotector without known toxic side effects. The present study was designed to examine the underlying radioprotective mechanism of H2 and its protective role on irradiated germ cells. Produced by the Fenton reaction and radiolysis of H2O, hydroxyl radicals (•OH) were identified as the free radical species that were red...

Journal: :Journal of oral science 2010
Fabrício M Tuji Maria Luiza dos A Pontual Silvana P Barros Solange M de Almeida Frab N Bóscolo

The aim of this study was to assess the radioprotective effects of sodium selenite on parotid glands in rats by ultrastructural analysis of acinar cells. Four experimental groups were assessed; control, irradiated, selenium, and selenium/irradiated. The sodium selenite dose was 0.5 mg/kg, administered intraperitoneally 24 h before irradiation in the head and neck region with a single 15-Gy dose...

2014
Thomas M. Seed Cynthia E. Inal Vijay K. Singh

PURPOSE Amifostine is a highly efficacious cytoprotectant when administered in vivo at high doses. However, at elevated doses, drug toxicity manifests for general, non-clinical radioprotective purposes. Various strategies have been developed to avoid toxic side-effects: The simplest is reducing the dose. In terms of protecting hematopoietic tissues, where does this effective, non-toxic minimum ...

Journal: :Journal of radiation research 2004
Zong-Wei Wang Jun-Min Zhou Zhao-Sheng Huang An-Ping Yang Zong-Chao Liu Yun-Fei Xia Yi-Xin Zeng Xiao-Feng Zhu

Polysaccharides from aloe are always considered an effective radioprotector on irradiation-induced skin damage. The aim of this study was to determine if aloe polysaccharides (AP) have radioprotective effects on normal human cells in vitro and mouse survival in vivo and to explore the mechanism. Pretreatment with 50 microg/ml AP could improve the surviving fraction at 2 Gy (SF2) of three normal...

Journal: :Life sciences 2014
Vijay K Singh Stephen Y Wise Jessica R Scott Patricia L P Romaine Victoria L Newman Oluseyi O Fatanmi

AIMS The objectives of this study were to determine the cytokine induction by delta tocotrienol (DT3, a promising radiation countermeasure) and to investigate the role of granulocyte colony-stimulating factor (G-CSF) in its radioprotective efficacy against ionizing radiation in mice. MAIN METHODS Multiplex Luminex was used to analyze cytokines induced by DT3 and other tocols (gamma-tocotrieno...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید