Abstract PURPOSE To investigate the effect of radiotherapy and surgery in patients with lung cancer brain metastases (BMs) poor prognosis factors. METHODS We analyzed retrospectively 714 BMs. A 1:1 propensity score matching (PSM) was performed to balance potential confounders. Analyses overall survival (OS) risk factors for OS were assessed by log-rank test Cox proportional hazard model. RESULT...

Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lun...

Combined chemotherapy and radiation therapy have started to replace the traditional local approach of thoracic radiotherapy alone for unresectable stage III non–small-cell lung cancer. By itself, thoracic radiotherapy provides local control and effective palliation of symptoms, but has a minimal effect on survival.[1-3] Novel schemes of radiation such as hyperfractionated radiation[4] and conti...

PURPOSE/OBJECTIVES To describe experiences during radiotherapy of patients suffering from lung cancer. DESIGN Inductive, qualitative. SETTING A radiotherapy department in the south of Sweden. SAMPLE 15 patients with lung cancer undergoing their second week of radiotherapy. METHODOLOGIC APPROACH Interviews were conducted in a hospital setting, transcribed, and content analyzed. MAIN RE...

In traditional Chinese medicine, Fuzi is widely used as an antitumor agent or an adjuvant medication combined with radiotherapy and chemotherapy, but its mechanism remains unclear. In this study, we investigated anti-tumor and immunoregulation efficacy of Fuzi combined with radiotherapy in mice with Lewis lung cancer (LLC). We found that Fuzi combined with radiotherapy significantly inhibited t...

Combined chemotherapy and radiation therapy have started to replace the traditional local approach of thoracic radiotherapy alone for unresectable stage III non–small-cell lung cancer. By itself, thoracic radiotherapy provides local control and effective palliation of symptoms, but has a minimal effect on survival.[1-3] Novel schemes of radiation such as hyperfractionated radiation[4] and conti...

background: oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. the administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. the present study aimed to evaluate the radioprotective efficacy o...

A third of patients with non-small cell lung cancer (NSCLC) present with un-resectable stage III locally advanced disease and are currently treated by chemo-radiotherapy but the median survival is only about 21months. Using an orthotopic xenograft model of lung carcinoma, we have investigated the combination of radiotherapy with the anti-angiogenic drug axitinib (AG-013736, Pfizer), which is a ...

Lung cancer is the leading cause of cancer-related deaths worldwide. Radiotherapy is one of the main treatment modalities of lung cancer. However, the achievable accuracy of radiotherapy treatment is limited for lung-based tumors due to respiratory motion. Four-dimensional (4D) radiotherapy explicitly accounts for anatomic motion by characterizing the motion, creating a treatment plan that acco...

AIMS AND BACKGROUND Evaluation of the metabolic response to radiotherapy in nonsmall cell lung cancer patients is commonly performed about three months after the end of radiotherapy. The aim of the present study was to assess with positron emission tomography/computed tomography (PET/CT) and [18F]fluorodeoxyglucose changes in glucose metabolism during and after radiotherapy in non-small cell lu...