In the last few years, the treatment of castration-resistant prostate carcinoma (CRPC) has changed completely. The approval of docetaxel and subsequent investigation in this field have led to development of new agents that have demonstrated an improvement in overall survival in the post-docetaxel setting, such as cabazitaxel and abiraterone. Radium-223 chloride is a radioisotope that has recent...

Background Six radium-223 injections at 4-week intervals is indicated for patients with castration-resistant prostate cancer and symptomatic bone metastases. However, patients usually develop disease progression after initial treatment. This prospective phase I/II study assessed re-treatment safety and efficacy of up to six additional radium-223 injections. Patients and methods Patients had c...

In man the study of the harmful effects in bone of internally deposited radioactive material has been made either on subjects who have been given radium compounds internally for medicinal purposes, a practice now discontinued, or on subjects who have accidentally ingested-radium, and sometimes mesothorium, while working as luminous-dial painters. The use of self-luminous paints for watch dials ...