نتایج جستجو برای: rank ligand
تعداد نتایج: 178783 فیلتر نتایج به سال:
Despite the importance of the receptor activator of nuclear factor (NF)-kappaB ligand (RANKL)-RANK signaling mechanisms on osteoclast differentiation, little has been studied on how RANK expression is regulated or what regulates its expression during osteoclastogenesis. We show here that insulin signaling increases RANK expression, thus enhancing osteoclast differentiation by RANKL. Insulin sti...
Patients with solid cancer frequently develop bone metastases (BM). Zoledronic acid (Zometa®, ZA), routinely used to treat patients with BM, acts on osteoclasts and also has antitumor properties. We aimed to assess the effect of ZA over time in novel bone turnover markers (RANK/receptor activator of nuclear factor-k B ligand (RANK-L)/ Osteoprotegerin (OPG)) and to correlate these with serum N-t...
Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is key to regulation for maintaining the balance between the activity of osteoblas...
BACKGROUND Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG. MATERIALS AND METHODS We examined mRNA expression levels of RANKL/RANK/OPG in a publicly ...
Biological sensory receptors provide excellent examples of microscopic scale information transduction amidst stochastic noise. We argue that stochasticity is not always a hindrance to sensing. Instead, it could allow single sensor perform multiplexing: simultaneously transducing multiple types environmental the downstream network. Through Langevin dynamics simulation ligand-receptor in bath lig...
Bone is a dynamic tissue that is maintained by continuous renewal. An imbalance in bone resorption and bone formation can lead to a range of disorders, such as osteoporosis. The receptor activator of NF-κB (RANK)-RANK-ligand (RANKL) pathway plays a major role in bone remodeling. Here, we investigated the effect of mutations at position I248 in the DE-loop of murine RANKL on the interaction of R...
لنگش از بیماری های مهم و سبب ضررهای اقتصادی و نیز دلیل اختلال در آسایش در گله های گاو شیری است. لنگش سبب تغییر رفتار طبیعی حیوان شده و بر این اساس اسکورهای مختلف حرکتی برای تشخیص آن به وجود آمده است از جمله manson & leaver ، sprecher و cook. دراین مطالعه، گاوداری صنعتی با 1300 راس گاو دوشا در منطقه شهرکرد انتخاب و در فواصل 3 ماهه(شهریور، آذر و اسفند) در این گاوداری به 300 راس گاوی که به صورت تص...
We prove that the filling order is quadratic for a large class of solvable groups and asymptotically quadratic for all Q-rank one lattices in semisimple groups of R-rank at least 3. As a byproduct of auxiliary results we give a shorter proof of the theorem on the nondistorsion of horospheres providing also an estimate of a nondistorsion
The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immun...
فرض کنیم w یک زیر مجموعه ناتهی از یک گروه آزاد باشد. خودریختی ? از یک گروه g را یک خودریختی حاشیه ای می نامیم اگر برای هر x?g داشته باشیم x^(-1) ?(x)?w^* (g)، جایی که w^* (g) زیرگروه حاشیه ای گروه g است. در این پایان نامه ثابت می کنیم که اگر g یک گروه باشد و w یک زیر مجموعه غیرتهی از f_? باشد به طوری که w^* (g)?w(g)?z(g)، آن گاه ?aut?_(w^* ) (g)?hom(g/w(g) ,w^* (g)) و هم چنین برای هر -pگروه متن...
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