crohn’s disease is an inflammatory bowel disease (ibd), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. environmental triggers and interaction of genetic determinants also play an indispensible role. in this case report, we present a pre-pubertal girl with intermittent and refra...

Advances in next-generation sequencing technology have enabled systematic exploration of the contribution of rare variation to Mendelian and complex diseases. Although it is well known that population stratification can generate spurious associations with common alleles, its impact on rare variant association methods remains poorly understood. Here, we performed exhaustive coalescent simulation...

Oral squamous cell carcinoma is rare in the pediatric population. When it does occur, it is most commonly seen on the tongue or lip. In this article, we report a rare case of squamous cell carcinoma of the maxillary gingiva and alveolus in a 10-year-old girl and review the literature concerning oral squamous cell carcinoma in the pediatric population.

conclusions the mtbdrplus and mtbdrsl genotypic testing can serve as useful additional tools for dst in a high-burden country like pakistan provided it is used in combination with phenotypic testing. results the sensitivity of mtbdrplus for isoniazid and rifampicin was found to be 88.8% and 90.2%, respectively, while sensitivity of mtbdrsl for fluoroquinolones, amikacin/capreomycin, and ethambu...

conclusions based on the location of detected rccs in the structure of hbv proteins, it was found that these rccs may have a critical role in correct folding of hbv proteins and can be considered as drug targets. the results of this study provide new and deep perspectives about structure of hbv proteins for further researches and designing new drugs for treatment of hbv. results the pfam search...

different samples have been prepared from different products in chadormalu iron ore concentrator plant: low intensity magnetite separators concentrate (magnetite concentrate), reverse flotation tail (final hematite concentrate), flotation concentrate (apatite concentrate), final tail (l.i.m.s. tail + reverse flotation concentrate+ apatite flotation tail). the samples were used for rare earth el...

this work was aimed to evaluate and compare the performances of the solvents d2ehpa (di-(2-ethylhexyl) phosphoric acid), cyanex 272 (bis (2,4,4-trimethylpentyl) phosphinic acid), and a mixture system of d2ehpa and cyanex272 in the separation of some rare earth elements (rees) including lanthanum, gadolinium, neodymium, and dyspersym from a nitric acid solution. the results obtained showed that ...

Count data sometimes exhibit a greater proportion of zero counts than is consistent with the data having been generated by a simple Poisson or negative binomial process. For example, a preponderance of zero counts have been observed in data that record the number of automobile accidents per driver, the number of criminal acts per person, the number of derogatory credit reports per person, the n...

A theory of exceptional extreme events, characterized by their abnormal sizes compared with the rest of the distribution, is presented. Such outliers, called “dragonkings”, have been reported in the distribution of financial drawdowns, city-size distributions (e.g., Paris in France and London in the UK), in material failure, epileptic seizure intensities, and other systems. Within our theory, t...

introduction: aneurysmal bone cysts (abc) are extremely rare in the head and neck region and even rarer in sinuses.  abc is a benign multicystic mass that is locally-destructive and rapidly expandable. hemorrhagic fluid content (like in this case) and septated appearance are the characteristic feature of abc. established treatment options for abcs include sclerotherapy, embolization, radiothera...