hypohidrotic ectodermal dysplasia (hed) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. the phenotype of hed is associated with mutation in eda, edar, edaradd and nemo genes, all of them disruptingnf-κb signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. here w...

splenic tuberculosis is a rare entity, particularly among immunocompetent hosts. hererin, we present a 23 year-old man who was reffered with fever of unknown origin and eventually diagnosed to have splenic tuberculosis with an involvement of a single axillary lymph node as the sole site disease in the other organs.despite two months of treatment with antituberculous agents due to necrotising gr...

cervical and supraclavicular lymph nodes metastases generally arise from carcinomas of the head and neck. metastases to cervical lymph nodes from the prostate are very rare. the common site for lymph node metastasis from the prostate is infradiaphrag- matic. herein, we report a 69 year-old male who presented with cervical lymph node enlargement in the setting of prostate cancer. this type of pr...

metastases of internal tumors to the oral cavity are unusual and in most cases involve maxilla and mandible. metastases to the gingival soft tissue are extremely rare. reporting a new clinical case of renal cell carcinoma (rcc) metastasis with an unusual site. metastatic involvement of gingival tissue with renal cell carcinoma is an extremely rare clinical event. it is usually associated with i...