Morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...

The evolution of texture during different mechanical processes is an integral part Integrated Computational Materials Engineering (ICME) metals and alloys. In the present work, PRISMS-Plasticity TM, open-source rapid analysis pipeline, based on Taylor model integrated into crystal plasticity software, PRISMS-Plasticity. However, unlike PRISMS-Plasticity, pipeline does not involve any finite ele...

In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...

One of the most prominent but least understood neuroanatornical features of the cerebral cortex is feedback. Neurons within a cortical area generally receive massive excitatory feedback from other neurons in the same cortical area. Some of these neurons, especially those in the superficial layers, send feedforward axons to higher cortical areas while others neurons, particularly those in the de...

Micropolar plasticity provides the capability to carry out post-failure simulations of geo-structures due to microstructural considerations and embedded length scale in its formulation. An essential part of the numerical implementation of a micropolar plasticity model is the integration of the rate constitutive equations. Efficiency and robustness of the implementation hinge on the type of int...

We show that the singular dissipative potential of the phenomenological rate-independent plasticity can be obtained by homogenization of a micro-model with quadratic dissipation. The essential ingredient making this reduction possible is a rugged energy landscape at the micro-scale, generating under external loading a regular cascade of subcritical bifurcations. Such landscape may appear as a r...

Bursts of activity in networks of neurons are thought to convey salient information and drive synaptic plasticity. Here we report that network bursts also exert a profound effect on Spike-Timing-Dependent Plasticity (STDP). In acute slices of juvenile rat somatosensory cortex we paired a network burst, which alone induced long-term depression (LTD), with STDP-induced long-term potentiation (LTP...