Background and objective: Five-membered heterocycle compounds having single oxygen nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole have a broad range of biological activities therapeutic value. In view strategic design antimicrobial compounds, several new ester-functionalized isoxazoles were synthesized characterized. Methods: A regioselective isoxazole incorporating an a...

A highly enantioselective dearomative Rautenstrauch rearrangement catalyzed by cationic (S)-DTBM-Segphosgold(I) is reported. This reaction provides a straightforward method to prepare enantioenriched cyclopenta[b]indoles. These studies show vast difference in enantioselectivity in the reactions of propargyl acetates and propargyl acetals in the chiral ligand-controlled Rautenstrauch reaction.

In view the of wide scope of structural information of biomolecules in biocompatible ionic liquids (ILs) in various applications including chemical and biochemical, it is essential to study the productive preferential interactions between biological macromolecules and biocompatible ILs. We have therefore explored the stability and activity of α-chymotrypsin (CT) in the presence of five ILs from...

The propargyl Claisen rearrangement is a known protocol to gain access to functionalized allenes through the [3,3]-sigmatropic transformation of propargyl vinyl ethers. The correct use of appropriate propargyl vinyl ethers as starting materials coupled with suitable reaction conditions can aid in the development of new domino methodologies in which the allenes are valuable intermediates in rout...

The title compound, C(17)H(18)N(2)O(2)S, was synthesized by aryl-sulfonyl-ation of 1-hy-droxy-methyl-1H-benzimidazole in the presence of triethyl-amine. The benzimidazole and benzene rings form a dihedral angle of 84.1 (1)°. The tert-butyl group was treated as rotationally disordered over two orientations in a 0.51 (2):0.49 (2) ratio. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds li...

Choline (Cho)-containing phospholipids are the most abundant phospholipids in cellular membranes and play fundamental structural as well as regulatory roles in cell metabolism and signaling. Although much is known about the biochemistry and metabolism of Cho phospholipids, their cell biology has remained obscure, due to the lack of methods for their direct microscopic visualization in cells. We...

The title compound, [NiBr(2)(C(27)H(27)NP(2))], was synthesized by the reaction of NiBr(2)(dme) (dme is 1,2-dimethoxy-ethane) with N,N-bis-(diphenyl-phosphino)isopropyl-amine in methanol/tetra-hydro-furan. The nickel(II) center is coordinated by two P atoms of the chelating PNP ligand, Ph(2)PN(iPr)PPh(2), and two bromide ions in a distorted square-planar geometry.

a simple and green synthesis of α-hydroxy phosphonates has been performed by reaction between aldehydes and triethyl phosphite using sodium dodecylphosphonate as anionic surfactant in micellar media under reflux conditions. the novel structures were recognized by 1h nmr, 13c nmr and 31p-nmr. the employ of green media, clean reaction profiles, simple experimental and work up procedures and high ...