نتایج جستجو برای: reactive astrocytes
تعداد نتایج: 171535 فیلتر نتایج به سال:
Injury to the central nervous system (CNS) invokes a reparative response known as astrogliosis, characterized largely by hypertrophy, proliferation and increased expression of glial fibrillary acidic protein (GFAP), resulting in reactive astrocytosis. Based on our prior observation that peritumoral reactive astrocytes express Vascular Endothelial Growth Factor (VEGF), a highly potent and specif...
Astrocytes react to brain injury in a heterogeneous manner with only a subset resuming proliferation and acquiring stem cell properties in vitro. In order to identify novel regulators of this subset, we performed genomewide expression analysis of reactive astrocytes isolated 5 days after stab wound injury from the gray matter of adult mouse cerebral cortex. The expression pattern was compared w...
Promotion of remyelination is an important therapeutic strategy to facilitate functional recovery after traumatic spinal cord injury (SCI). Transplantation of neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) has been used to enhance remyelination after SCI. However, the microenvironment in the injured spinal cord is inhibitory for oligodendrocyte (OL) differentiation of NSCs o...
INTRODUCTION: Following injury or insult, failure of the injured CNS to repair is in part attributed to the inhibitory environment of the lesion site, most notably the formation of the glial scar. This consists predominantly of astrocytes, which exhibit a reactive hypertrophic phenotype exemplified by upregulation of various markers, including GFAP. In vitro models have been employed to explore...
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