background: breast cancer is one of the most prevalent malignancies among women in various countries. her2 overexpression, which is due to different reasons, occurs in 20-30% of breast cancers. her2 gene encodes an 185kda transmembrane glycoprotein with 1255 amino acids. this active product triggers downstream intracellular signaling pathways inducing cell proliferation and cell survival. these...

This paper presents an efficient optimization procedure to find the optimal shapes of double curvature  arch  dams  considering  fluid–structure  interaction  subject  to  earthquake  loading. The optimization is carried out using a combination of the magnetic charged system search, big bang-big crunch algorithm and artificial neural network methods. Performing the finite element  analysis  dur...

nowadays, due to inherent complexity of real optimization problems, it has always been a challenging issue to develop a solution algorithm to these problems. single row facility layout problem (srflp) is a np-hard problem of arranging a number of rectangular facilities with varying length on one side of a straight line with aim of minimizing the weighted sum of the distance between all facility...