Background: Estradiol and progesterone as well as hippocampal GABAA receptors are believed to play a role in the modulation of pain. The aim of present study was to investigate the effect of intrahippocampal injections of GABAA receptor agonist (muscimol) and GABAA receptor antagonist (picrotoxin) on pain sensitivity during estrous cycle. Methods: Pain sensitivity was evaluated in rats ...

We used the Life Orientation Test-Revised (LOT-R) as a unidimensional scale to investigate the stability of dispositional optimism and compared the results with the stability of anxiety and depression. Five hundred and twelve women completed the LOT-R and the Hospital Anxiety and Depression scale before follow-up mammography and 4 weeks after receiving the result (breast cancer or not). This st...