N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key roles in excitatory synaptic transmission. Because of their involvement in numerous neurological disorders, NMDARs are also targets of therapeutic interest. NMDARs occur as multiple subtypes which differ in their subunit composition and in their biophysical and p...

Lack of Transferrin Receptor 1 in the Heart Causes Lethal Cardiomyopathy and Disruption of Mitophagy in Mice by Wenjing Xu Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Nancy C. Andrews, Supervisor ___________________________ Matthew D. Hirschey ___________________________ Deborah M. Muoio _______________________...

Adolescent Response to THC: Greater Learning Impairment and Lesser Cannabinoid CB1 Receptor Desensitization in Adolescents Than Adults. by Nicole Leigh Tadisch Moore Department of Pharmacology Duke University Date:_____________ Approved: __________________________ Cynthia M. Kuhn, Supervisor __________________________ Allyn C. Howlett __________________________ J. Victor Nadler ________________...

A39 Long-term depression-like effect of a single immune challenge in neuropeptide Y Y2 and Y4 receptor knockout mice Evelin Painsipp, Herbert Herzog, Günther Sperk and Peter Holzer Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria Neurobiology Research Program, Garvan Institute of Medical Res...