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BACKGROUND/AIMS The aim of the present study was to investigate whether Helicobacter pylori causes or triggers recurrent aphthous stomatitis (RAS) through cytokine gene polymorphism and/or cobalamin deficiency. MATERIALS AND METHODS Thirty-six patients with RAS and 130 patients without RAS were genotyped for IL-1β (-511C/T) and IL-6 (-174G/C) and evaluated for H. pylori infection and serum co...

INTRODUCTION AND OBJECTIVES Recurrent aphthous stomatitis (RAS) is the most common type of ulcerative disease of the oral mucosa. Despite its worldwide occurrence and the extensive amount of research that has been devoted to the subject, the etiology of RAS remains unclear. Nevertheless, several hereditary, nutritional, infectious and psychological factors have been associated with RAS. The aim...

n the article entitled “Two-year prevalence of minor aphtha in Tabriz, Northwest Iran” which was published in the winter issue of the third volume of the journal, a 0.3% prevalence rate for minor recurrent aphthous stomatitis (RAS) was reported. We attempted to continue studying the archives of Tabriz University of Medical Sciences Faculty of Dentistry until June 2008, to allow for a consecutiv...

PURPOSE To study the effect of smoking on the prevalence of recurrent aphthous stomatitis (RAS) and to examine whether intensity and duration of smoking influence RAS lesions. SUBJECTS AND METHODS A cross-sectional survey was conducted on a random sample of 1000 students of The University of Jordan, Amman, between May and September 2008. Sociodemographic factors and details about smoking habi...

AIM The aim of this report is to present the management of a patient with pernicious anemia afflicted with recurrent aphthous stomatitis (RAS). BACKGROUND RAS is one of the most common lesions of the oral mucosa. Although the exact etiology of RAS is still unknown different hematinic deficiencies have been proposed. CASE REPORT Painful recurrent ulcers covered with a grayish pseudomembrane ...

BACKGROUND Recurrent aphthous stomatitis (RAS) is an ulcerative disease of the oral mucosa without a clearly defined etiology. The aim of the study was to evaluate the serum zinc levels in patients with RAS in comparison to healthy controls and to validate the association between zinc levels and the course of RAS. METHODS Seventy-five patients with RAS and 72 controls underwent full dental ex...

Honey is the nectar that is collected from many plants and processed by honey bees (Apis mellifera). This study is a pilot study that observes and evaluates the clinical efficacy of topical application of honey bees in treatment of some common inflammatory, vesiculobullous and ulcerative oral lesions. A total number of 50 patients complaining of different oral lesions were enrolled in this stud...

BACKGROUND Recurrent aphtous ulcers (RAUs) are of the most painful and common oral mucosal diseases with uncertain etiology including trauma, genetics, stress, immune dysfunction, and vitamin deficiencies. The aim of this study was to investigate the relationship between oral health impacts, patients' oral health-related quality of life and anxiety and depression in patients with recurrent apht...

BACKGROUND Recurrent aphthous stomatitis (RAS) is a chronic relapsing inflammatory disorder of the oral mucosa with unknown etiology. Oxidative stress (OS) is suggested to play a main role in the etiopathogenesis in RAS. OBJECTIVE In this study, we hypothesize that a systemic OS is present in patients with RAS. METHODS Forty-four patients with active RAS lesions and 38 healthy controls were...