Characterizing the genetic alterations leading to the more aggressive forms of oestrogen receptor-positive (ER+) breast cancers is of critical significance in breast cancer management. Here we identify recurrent rearrangements between the oestrogen receptor gene ESR1 and its neighbour CCDC170, which are enriched in the more aggressive and endocrine-resistant luminal B tumours, through large-sca...

Types and treatment of breast cancer recurrence Recurrence describes the return of breast cancer after primary treatment.1 There are three types of recurrent breast cancer:1 • Local recurrence occurs when cancerous cells reappear at the original tumour site over time. Local breast cancer recurrence is not considered to be a spread of the cancer but rather due to failure of the initial treatment...

BACKGROUND Bevacizumab has been increasingly used in combination chemotherapy with paclitaxel for treatment of metastatic or recurrent breast cancer. The aim of this report is to underline possible risks associated with the new combination chemotherapy. CASE PRESENTATION A 39-year-old woman with recurrent breast cancer was treated with bevacizumab and paclitaxel. Positron emission tomography ...

PURPOSE To report the treatment effect of interstitial brachytherapy for chest wall locoregional recurrence of breast cancer. MATERIAL AND METHODS This 44-year-old female presented with chest wall recurrence seven years after modified radical mastectomy for stage II breast cancer. Despite external beam radiation and chemotherapy, the lesion expanded as 5.3 × 5.1 × 3.0 cm(3), and 8.0 × 5.1 × 4...

Axillary recurrence of breast cancer that involves the brachial neurovascular bundle is uncommon. However, for many patients with such recurrence, forequarter amputation can play a palliative role in relieving excruciating pain and paralysis of the upper limb. Further, for those patients who do not have distant metastasis or other local-regional recurrence, forequarter amputation provides a cha...

Breast cancer mortality is principally due to recurrent tumors that arise from a reservoir of residual tumor cells that survive therapy. Remarkably, breast cancers can recur after extended periods of clinical remission, implying that at least some residual tumor cells pass through a dormant phase prior to relapse. Nevertheless, the mechanisms that contribute to breast cancer recurrence are poor...

BACKGROUND Systematic treatments such as hormone and chemotherapy are selected according to tumor characteristic after major therapeutic approaches such as surgery. This study attempted to analyze and compare the status of Estrogen Receptor (ER) and Progesterone Receptor (PR) in primary and recurrent sites of breast cancer in patients. METHODS We reviewed all medical records of breast cancer ...

Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The objective of this study was to identify a tissue microRNA (miRNA) signature that predicts prognosis in young breast cancer patients. Total RNA from...

background: women with the medical history of breast cancer constitute the biggest group of patients who survived cancer. despite the high rate of mastectomy after breast cancer in iran only limited patients elect reconstruction surgery. the aim of our study was to evaluate the rate of tendency to breast reconstruction (br) surgery among women with breast cancer who had mastectomy but not under...

[no abstract available]