Recurrent pregnancy loss (RPL) is a multifactorial condition. Approximately half of patients with RPL will have no explanation for their miscarriages. De novo chromosome abnormalities are common in sporadic and recurrent pregnancy loss. Testing for embryonic abnormalities can provide an explanation for the miscarriage in many cases and prognostic information. Regardless of the cause of RPL, pat...

UNLABELLED The clinical and laboratory features as well as the diagnostic and therapeutic approach of men with XYY syndrome have not been fully described. A 41-year-old infertile man was diagnosed as having a 47,XYY karyotype and a micro-prolactinoma. His 32-year-old wife had a history of five spontaneous pregnancies, all resulting in first trimester miscarriages. Three in-vitro fertilization (...

We report two patients where the finding of isolated fetal hydrocephalus led to the detection of severe fetal thrombocytopenia, using fetal blood sampling. Serological investigation led to the diagnosis of fetomaternal alloimmune thrombocytopenia (FMAIT) due to anti-HPA-1a. Both women had had previous unsuccessful pregnancies probably due to FMAIT; one had had four miscarriages at 17-18 weeks' ...

.. Objectives: The rationale of our study is to investigate whether aspirin alone, or aspirin combined with low molecular weight heparin as compared to placebo (intensive pregnancy surveillance), would improve the live birth rate (primary outcome) among with idiopathic recurrent miscarriages. Secondary outcomes included rate of serious adverse events during pregnancy among pharmacological inter...

Recurrent pregnancy loss (RPL) refers to the consecutive loss of three or more clinically recognized pregnancies prior to the 20th week of gestation (excluding ectopic, molar and biochemical pregnancies). RPL is classified into two categories: primary RPL, which consists of repeated miscarriages in which a pregnancy has never been carried to viability; and secondary RPL, in which a live birth h...

This was a prospective clinical trial conducted at Khartoum Fertility Center, during the period June 2002 to February 2005 to investigate the efficacy of unfractionated heparin and low-dose aspirin as prophylaxis against pregnancy loss in 58 pregnant Sudanese women with recurrent (> or = 3) miscarriages associated with antiphospholipid syndrome (APS). Three (5.1%) patients had early miscarriage...