BACKGROUND AND METHODS Alcohol abuse is one of the most common causes of seizures in adults. In a randomized, double-blind study, we compared lorazepam with placebo for the prevention of recurrent seizures related to alcohol. Over a 21-month period, we studied consecutive patients with chronic alcohol abuse who were at least 21 years of age and who presented to the emergency departments of two ...

background : glenoid bone damages consisting of anterior rim erosion and bony avulsion are very important in decision making for treatment of recurrent dislocation in shoulder joint. this study was aimed to determine the prevalence of these damages in patients with anterior recurrent shoulder dislocation. methods : the study was a cross-sectional study evaluating patients with unstable shoulder...

Epilepsy, which is characterized by the risk of recurrent seizures, is a chronic disease that afflicts about 200,000 Canadians at any one time. Dentists with a thorough knowledge of seizure disorders and the medications used to treat them can provide necessary dental and oral health care to these patients. In this review, we summarize current knowledge of epilepsy, seizures and antiepileptic dr...

Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures. IL-6 levels were increased after seizures, whereas sIL-6R levels were decreased. Interestingly, the levels o...

The epilepsies are a heterogeneous group of disorders characterized by the propensity to experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the underlying mechanisms of seizure initiation, seizure propagation, and comorbid conditions are incompletely understood. Metabolic changes including the production of reactive species are known to result from prolonged s...

Persistent seizures and failure to regain consciousness following witnessed seizure activity require emergency neurological consultation. Although outcome is largely dependent on underlying cause, early maximal anticonvulsant therapy is critical to reducing morbidity. This review covers important concepts in the clinical and EEG diagnosis of status epilepticus, and discusses treatment algorithm...

Corpus callosotomy (CC) has been employed in the management of intractable epilepsy since 1940’ and should be considered for patients with generalized falling seizures with physical injury, recurrent life-threatening generalized convulsive status epilepticus or atypical absence status’. CC is especially useful in improving seizure control in patients with tonic and atonic seizures3 and those wi...

conditions and is characterized by spontaneous recurrent seizures.1 Understanding the pathophysiology of seizure initiation and termination has important implications for our ability to manage seizure disorders, and for the potential development of novel anti-epileptic agents. Previous research in our laboratory2 and others3-5 have shown that cannabinoid compounds such as WIN55,212-2 are anti-e...

'Mah-jong epilepsy' is a rare reflex epilepsy syndrome, manifesting as recurrent epileptic seizures triggered by either playing or just watching mah-jong. We present three patients with this condition and review all the reported cases. Mah-jong-induced seizures can be considered a subtype of cognition-induced epilepsy. Nonetheless, these patients have distinctive clinical and electrophysiologic...

tatus epilepticus is a serious and potentially life-threatening medical emergency that requires prompt intervention. The traditional definition of status epilepticus is any seizure lasting longer than thirty minutes regardless of whether consciousness is impaired, or recurrent seizures without an intervening period of consciousness between seizures. Clinically, the average seizure is less than ...