Background Metformin improves cardiovascular outcomes in diabetes, but its mechanism of action is controversial. Recent evidence suggests that Metformin reduces gluconeogenesis by altering hepatic redox state. Whether Metformin also alters cardiac redox state and metabolism is unknown, in part because of the difficulty in measuring cardiac metabolism in vivo. Hyperpolarized [1-C]pyruvate magnet...

The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox switching mechanism by which Mtb WhiB3 under defined oxidizing and reducing conditions differentially modulates the assimilation of propionate into the complex virulence polyketides polyacyltrehaloses (PAT), sulfolipids ...

a new potassium persulfate redox system has been investigated for the graft polymerization of vinyl monomers. in this study potassium persulfate system was used for initiation the polymerization. graft polymerization of acrylonitrile (an) onto starch (sta) was carried out in aqueous solution using potassium persulfate (i) redox system. it was found that the percentage of grafting and rate of gr...

School of Pharmacy, Showa University, Ha Japan. E-mail: [email protected] Quantitative RedOx Sensing Team (QRST), Radiation Damages, National Institute of Institutes for Quantum and Radiological S Chiba 263-8555, Japan Division of Innovative Research for Drug Osaka University, Suita, Osaka 565-0871, Ja Department of Chemistry and Nano Scienc 750, Korea Faculty of Science and Technology, ...

Regulation of signal transduction and gene expression is a multifaceted process involving ligands, receptors, and second messengers that trigger cascades of protein kinases and phosphatases and propagate the signal to the nucleus to alter gene expression. Reduction-oxidation (redox)-based regulatory pathways provide additional means of gating signal transduction, and redox-based regulation of g...

Reactive oxygen species (ROS) can be generated during the course of normal aerobic metabolism or when an organism is exposed to a variety of stress conditions. It can cause a widespread damage to intracellular macromolecules and play a causal role in many degenerative diseases. Like other aerobic organisms plants are also equipped with a wide range of antioxidant redox proteins, such as superox...

The redox properties of sulfite ion has been examind using cyclic voltammetry in acetonitrile solvent at the surface of gold, pelatin and glassy carbon electrodes. It has bben found tha, sulfite ion exhibits two electron oxidation peak with EC’ mechanism. A novel chemically modified electrode containing Prussian blue complex and multi wall carbon nanotubes (MWCNs) was achieved on the surface of...

Developing highly active and robust oxygen evolution reaction (OER) electrocatalysts is still a critical challenge for water electrolyzers metal–air batteries. Realizing the dynamic of intermediate charge transfer during OER developing clear mechanism crucial to design high-performance catalysts. Recently in Nature, Xue colleagues revealed new mechanism, coupled (COM), which involves switchable...

Oxidation-reduction (redox) based regulation of signal transduction and gene expression is emerging as a fundamental regulatory mechanism in cell biology. Electron flow through side chain functional CH2-SH groups of conserved cysteinyl residues in proteins account for their redox-sensing properties. Because in most intracellular proteins thiol groups are strongly "buffered" against oxidation by...