Neurons differ in their responses to injury, but the underlying mechanisms remain poorly understood. Using quantitative proteomics, we characterized the injury-triggered response from purified intact and axotomized retinal ganglion cells (RGCs). Subsequent informatics analyses revealed a network of injury-response signaling hubs. In addition to confirming known players, such as mTOR, this also ...

By VIcroR PERMAN, EUGENE P. CRONKITE, VIcroR P. Bonn AND D u K. SORENSEN T HE SUCCESSFUL treatment of the hemopoietic phase of the acute irradiation syndrome m dogs following doses of radiation that are in the range of LD,00130 dose has been reported by Sorensen et a!.’ and Bagadasarov et al.2 The present study is concerned with the ability of hemopoietic tissue to regenerate spontaneously foll...

PURPOSE Guided bone regeneration (GBR) is the most widely used technique to regenerate and augment bones. Even though augmented bones (ABs) have been examined histologically in many studies, few studies have been conducted to examine the biological potential of these bones and the healing dynamics following their use. Moreover, whether the bone obtained from the GBR procedure possesses the same...

Background: There is a worldwide effort to present novel approaches for the development of tolerance-induction treatments in regenerative medicine, after years of investigation in clinical transplantation. Particularly, novel approaches are based on controlling the immune response, including the application of biomaterials or imitation of antigen-specific peripheral tolerance in either solid-or...

various materials and techniques have been used in the treatment of periodontal disease to achieve regeneration of lost periodontal tissues including cementum, periodontal ligament (pdl) and alveolar bone. the composition, regenerative potential, application and therapeutic characteristics of several regenerative materials have been evaluated in the present study

Duchenne muscular dystrophy is one of the most devastating myopathies. Muscle fibers undergo necrosis and lose their ability to regenerate, and this may be related to increased interstitial fibrosis or the exhaustion of satellite cells. In this study, we used mdx mice, an animal model of Duchenne muscular dystrophy, to assess whether muscle fibers lose their ability to regenerate after repeated...

in this study, the performance of an irreversible regenerative brayton cycle is sought through power maximizations using finite-time thermodynamic concept in finite-size components. optimizations are performed using a genetic algorithm. in order to take into account the finite-time and finite-size concepts in the current problem, a dimensionless mass-flow rate parameter is used to deploy time v...

Mesenchymal stem cells (MSCs) possess a battery of unique properties which make them ideally suited not only for cellular therapies/regenerative medicine, but also as vehicles for gene delivery in a wide array of clinical settings. These include: 1) widespread distribution throughout the body; 2) ease of isolation and ability to be extensively expanded in culture without loss of potential; 3) t...

Recent findings in stem cell biology have opened a new window in regenerative medicine. The endometrium possesses mesenchymal stem cells (MSCs) called endometrial stem cells (EnSCs) having specific regenerative properties linked to adult stem cells. They contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. Many clinical trials were undertaken to asce...

In this issue of Blood, Zhang et al describe an exciting new small-molecule antagonist of CXCL12-CXCR4 binding with a potent ability to mobilize hematopoietic stem cells (HSCs). Further clinical development of this new drug,Me6TREN, may have broad applications in stem-cell mobilization for cancer and in regenerative medicine.