Single-stranded DNA (ssDNA) with repetitive sequence was demonstrated to be a versatile nanotemplate for introducing biological activity in a self-assembled manner. Re-functionalization and rejuvenation of the ssDNA nanotemplate were achieved under mild biological conditions without using high temperature and strong alkaline treatment to denature DNA.

In this article, we present a novel robotic system for skin photo-rejuvenation, which uniformly delivers laser thermal stimulation to subject’s facial tissue. The robotized treatment is performed by customized manipulator instrumented with cosmetic generator, depth sensor, and camera. To plan the optimal trajectory of manipulator, our computes surface model face segments it into seven re...

Induced pluripotent stem (iPS) cells have provided a rational means of obtaining histo-compatible tissues for 'patient-specific' regenerative therapies (Hanna et al. 2010; Yamanaka & Blau 2010). Despite the obvious potential of iPS cell-based therapies, there are certain problems that must be overcome before these therapies can become safe and routine (Ohi et al. 2011; Pera 2011). As an alterna...

A novel self-induced non-ablative threedimensional fractional FRAC3 method for skin rejuvenation is described. The method utilizes short pulse duration/high peak power density of Nd:YAG Accelera mode laser pulses. The Accelera pulses produce a three-dimensional fractional pattern in the epidermis and dermis, with damage islands located predominantly at the sites of skin imperfections. Thermal m...

Introduction Anatomical nasal tissues include bone, cartilage, muscles, subcutaneous layer, and skin. All these elements are carefully organized to allow proper physiology and adequate aesthetics. These variables have been extensively studied and published, principally related to the corrections of development or post-traumatic abnormalities. Nasal surgical corrections have focused on re-establ...

While Software Aging and Rejuvenation (SAR) research has been steadily increasing, the artifacts related to SAR studies (such as software aging measurements and bug datasets) are seldom made available to researchers and practitioners, thus limiting potential improvements of rejuvenation solutions and their practical adoption. We discuss in this paper the role of artifacts in SAR research, and p...

This paper proposes an approach to estimate an optimal software rejuvenation schedule minimizing an expected total software cost per unit time. Based on a non-parametric predictive inference (NPI) approach, we derive the upper and lower bounds of the predictive expected software cost via the predictive survival function from system failure time data, and characterize an adaptive cost-based soft...

Aim: The aim of this literature review is to evaluate the efficacy microneedling treatment with injectable platelet-rich fibrin (i-PRF) for facial skin rejuvenation applications, using an objective analysis system and validated patient-reported outcome measures.