PURPOSE Long-acting gonadotropin-releasing hormone agonists (GnRHa) are commonly used to treat central precocious puberty (CPP) in Korea. Although rare, there have been reports on the characteristic of adverse reactions of GnRHa in CPP among the Korean population. This study was intended to report on our clinical experience regarding significant adverse reactions to long-acting GnRHa in CPP and...

In recent years, consumers have become empowered to share personal experiences regarding prescription drugs via Web page discussion groups. This paper describes our recent research involving automatically identifying adverse reactions from patient-provided drug reviews on health-related web sites. We focus on the statin class of cholesterol-lowering drugs. We extract a complete set of side effe...

joint pain is one of the most common complaints with many possible causes.some medicines used for joint pain relief such as nsaids have substantial and frequent side effects. topical route possibly reduces adverse reactions by maximizing local delivery and minimizing systemic toxicity. throughout history, plants have been the most important sources of medicines for human health and iranian trad...

BACKGROUND Along with efficacy, Chinese medicine is increasingly being known to people, Chinese medicine and its preparations are increasingly widespread in clinical use. People generally believe that Chinese medicine has few side effects and is safe, especially Chinese medicine injections. Due to the direct injection in blood, rapid onset and good efficacy, they are welcomed by people. However...

BACKGROUND Current German or UK package leaflets do not contain an explicit notice that the listing of side effects does not imply that they are caused by the drug. Causal interpretations by patients and lay people are frequently observed. The authors examined whether health professionals understand that there is not necessarily a causal relation between drug intake and the frequency of side ef...

The paper reviews data on biological side-effects of dental materials on patients and also on personnel who routinely handle the materials. The incidence of adverse effects is low--in one study indicated to be 1:700 for all types of treatments. For individual types of materials, it will be significantly lower, and for restorative materials, probably in the 1:10,000 to 1:20,000 range. Allergic r...

PURPOSE The adverse reactions of the iodinated contrast media are believed to be non-IgE mediated and the result of triggering of the release of the mast cell mediators directly. However, the exact mechanism is still controversial and purpose of this prospective study is not only to determine any possible correlation of adverse reactions with total baseline blood IgE levels, but also to investi...

background: mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (ivig). anti-iga antibody has been proposed to be associated with development of such reactions.   objective: to assess the association between anti-iga levels of different isotypes and adverse reactions induced in immunodeficient pati...