Arachidonic acid (AA) is released from cells after nervous tissue injuries.We treated rat cortical neurons and astrocytes cultured under normoxic or simulated ischemic conditions with N-acetylcysteine (100 or 200 microM) or ebselen (10 or 20 microM). N-acetylcysteine decreased AA release in normoxic astrocytes, while ebselen decreased AA release from astrocytes in both conditions. N-acetylcyste...

26 The Ca dependence of synaptic quantal release is generally thought to be restricted to 27 probability of vesicular release. However, some studies have suggested that the number of release sites 28 (n) at the neuromuscular junction (NMJ) is also Ca dependent. In the present study, we recorded 29 endplate currents over a wide range of extracellular Ca concentrations and found the expected Ca 3...

patients and methods fifty nine patients with indication for carpal tunnel release randomly assigned into two groups: open (n=30) or knifelight (n=29). the patients compared regarding scar length, operation duration, time to return to daily activities and amount of pain at three weeks after operation based on visual analog scale. results there was no significant differences regarding age and se...

objective(s): in this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  materials and methods: paclitaxel (ptx) loaded polylactic acid (pla) nanofibers were prepared by electrospinning. the effects of process parameters, such as ptx concentration, tip to collector distance, voltage, temperature and flow rate...

Controlled release fertilizers (CRF) are produced with different rates and durations of nutrient release to cater to different crops with wide ranges of nutrient requirements. A rapid technique is needed to verify the label specifications of nutrient release rate and duration. Polymer-coated urea (PCU) (43% nitrogen [N]) and polymer-coated N, phosphorus (P), potassium (K) (PC_NPK; 14-14-14) fer...

N-(3,4-Dimethoxycinnamoyl) anthranilic acid (N-5') is an inhibitor of IgE-mediated histamine release from mast cells. To elucidate inhibition mechanism, effects of N-5' were examined under various conditions using peritoneal exudate cells and isolated mast cells of rats. N-5' inhibited histamine release induced by antigen, ionophore A23187, ATP, dextran and phospholipase A2. But the release ind...

An increase of serum creatine kinase (CK) has been observed in clinical studies of nitrogen-containing aminobisphosphonates (N-BPs). Osteoclasts are thought to be the source of the CK, but there is no clear evidence for the hypothesis. In this study, CK release from rabbit osteoclasts induced by N-BPs was examined in an in vitro culture system. Rabbit bone-derived cells were cultured for 3 days...

objective: in dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. in this study, gentamicin was loaded into polylactic co-glycolic acid (plga) microspheres and its release pattern was evaluated for 20 days.   methods: in this experimental study, plga microspheres loaded with gentamycin were produced by the w/o/w method. t...