there are wide individual differences in pharmacokinetic parameters of mycophenolate mofetil (mmf) among transplanted patients. some studies have shown that single nucleotide polymorphisms (snps) of the uridine diphosphate glucuronosyl transferase1a9 (ugt1a9) are responsible for these differences in early days after transplantation. therefore it was decided to evaluate the influence of ugt poly...

Recognition of the natural history and responsible leading factors for regression of left ventricular hypertrophy after successful renal transplantation are very important. The aim of this study was to assess the regression of left ventricular hypertrophy after successful renal transplantation among uremic patients. In this study 27 uremic patients (18 males and 9 females) with an average a...

Increased intima-media thickness of the carotid arteries (cIMT) has been found in young adults with childhood-onset chronic kidney disease (CKD). The disease stage at which these patients first develop abnormalities of arterial texture is unknown. The objective of this study was to determine the onset and character of arterial changes in children aged 10 to 20 yr with different stages of CKD an...

Vitamin D deficiency is frequently found in patients with renal transplants (RTxs). Because vitamin D plays indispensable roles in the immune system, there may be an association between vitamin D deficiency and infection in these patients, but this has not been fully elucidated. Therefore, this study investigated the impact of pre-RTx vitamin D deficiency on urinary tract infection (UTI) develo...

This study aimed to investigate the expression levels of the Raf kinase inhibitor protein (RKIP) and NF-κB in renal tissues of diabetic nephropathy (DN) rats, and to determine the underlying molecular targets of rituximab (RTX), with the goal of developing new clinical treatment selection for DN. Sprague-Dawley rats were randomly divided into a normal group (N), a DN group (M), and an RTX treat...

results implementation of modern techniques of immune monitoring, allograft function, awareness about the specific infectious and non-infectious disease in each region improves the quality of renal transplantation. conclusions we need to combine the advance scientific vision with local vigilance to achieve the best outcome in renal allograft recipients evidence acquisitions in this process we s...

BACKGROUND The aetiology and outcome of acute (ARF) and chronic renal failure (CRF) in infants were analysed in a retrospective study. METHODS Between January 1997 and April 2004 all children <1 year of age with a serum creatinine >100 mumol/l at Hannover Medical School were followed up for up to 6 years. One hundred and nineteen children with a serum creatinine >100 mumol/l were identified, ...

Advances in nephrology and pediatric urology have increased the number of children who survive renal disease and become candidates for renal transplantation. Ten years of experience in pediatric renal transplantation are reviewed to determine the rates of patient morbidity and graft survival. Of the 450 renal transplantations performed in Imam Reza Hospital (1989- 1999), fifty-one were don...

BACKGROUND Approximately 30% of adult patients with immunoglobulin A (IgA) nephropathy (IgAN) or IgA vasculitis with nephritis (IgAVN) develop end-stage renal disease during long-term follow-up. In particular, patients with nephritic-nephrotic syndrome have an increased risk of rapid progression. Conventional immunosuppressive therapy with corticosteroids (CSs) may be insufficient for disease c...