Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disorder of the CNS caused by infection of glial cells with the polyomavirus, JCV. Here we report that genomic stability and DNA repair are significantly dysregulated by JCV infection of human astrocytes. Metaphase spreads exhibited increased ploidy correlating with duration of infection. Increased micronuclei formation a...

Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1-dependent G2 checkpoint activation and sensitizes cells to senescence through enhancement of mit...

Objective: To compare the outcome of two tension free methods hernia repair: laparoscopic mesh repair versus open technique in terms severity chronic post-operative pain. Material and methods: In this randomized controlled trial, total 100 male patients with inguinal hernia, age between 20-60 years were selected from Department Surgery, Arif Memorial Teaching Hospital Lahore. Duration study was...

PURPOSE The purpose of this study was to investigate the risk factors for urethrocutaneous fistula development after hypospadias repair. MATERIALS AND METHODS Between January 1990 and May 2010, 348 patients underwent hypospadias repair. This study included 294 patients who were followed up for more than 6 months. Potential risk factors for the development of fistula after operation included a...

BACKGROUND Incisional hernias occur at surgical abdominal incision sites, but the association with caesarean section (CS) has not been examined. AIM To determine whether CS is a risk factor for incisional hernia repair. MATERIALS AND METHODS Population-based cohort study in Australia using linked birth and hospital data for women who gave birth from 2000 to 2011. Survival analysis was used ...

Lithium containing droplet and cluster targets irradiated by laser pulses are proposed as prospective source of for soft x-ray lithography. Analytical model and simulations show that laser with repetition rate of several MHz with energy of several mJ and pulse duration 10 ps is required.

We show that according to the GRB internal shock model the pulse duration and the interval between neighboring pulses are correlated and have a similar distribution. We analyze a sample of bright long bursts and find that the pulses duration have a lognormal distribution while the intervals has an excess of long intervals (relative to lognormal distribution). This excess can be explained by the...

BACKGROUND Literature regarding the outcomes of revision rotator cuff repair is limited. The purposes of the present study were to report the tendon repair integrity and clinical outcomes for a cohort of patients following revision arthroscopic rotator cuff repair and to examine factors related to tendon healing and the influence of healing on clinical outcomes. METHODS Twenty-one of twenty-n...

Objective: To compare Sublay and Onlay mesh repair in terms of post-operative complications among patients undergoing hernioplasty.
 Study Design: Prospective comparative study.
 Place Duration Study: Surgical Department, Combined Military Hospital, Rawalpindi Pakistan, from Jan 2020 to Jun 2021.
 Methodology: This study was conducted on 300 who underwent hernioplasty for anterio...