نتایج جستجو برای: reperfusion oxidant

تعداد نتایج: 50938  

2016
Eylem Taskin Kadir Ali Tuncer Celal Guven Salih Tunc Kaya Nurcan Dursun

BACKGROUND Myocardial ischemia and reperfusion lead to impairment of electrolyte balance and, eventually, lethal arrhythmias. The aim of this study was to investigate the effects of pharmacological inhibition of angiotensin-II (Ang-II) production on heart tissue with ischemia-reperfusion damage, arrhythmia, and oxidative stress. MATERIAL AND METHODS Rats were divided into 4 groups: only ischemi...

2011
Grazyna Nowak Diana Bakajsova Allen M. Samarel

Nowak G, Bakajsova D, Samarel AM. Protein kinase C-ε activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules. Am J Physiol Renal Physiol 301: F197–F208, 2011. First published February 2, 2011; doi:10.1152/ajprenal.00364.2010.—PKC-ε activation mediates protection from ischemia-reperfusion injury in the myocardium. Mitochondria are a subcellular target of these pr...

Journal: :American journal of physiology. Heart and circulatory physiology 2008
Guillaume Chanoit SungRyul Lee Jinkun Xi Min Zhu Rachel A McIntosh Robert A Mueller Edward A Norfleet Zhelong Xu

The purpose of this study was to determine whether exogenous zinc prevents cardiac reperfusion injury by targeting the mitochondrial permeability transition pore (mPTP) via glycogen synthase kinase-3beta (GSK-3beta). The treatment of cardiac H9c2 cells with ZnCl2 (10 microM) in the presence of zinc ionophore pyrithione for 20 min significantly enhanced GSK-3beta phosphorylation at Ser9, indicat...

Journal: :The European respiratory journal 1999
E A Williams G J Quinlan P B Anning P Goldstraw T W Evans

Lung resection may be complicated by postpneumonectomy pulmonary oedema. Oxidant generation following surgery-induced ischaemia-reperfusion may be responsible. This hypothesis was tested utilizing isolated, in situ, blood perfused rodent lungs subjected to continuous perfusion (control subjects); one lung ventilation followed by pneumonectomy (group 1); or one lung ventilation followed by reinf...

a:4:{s:9:"Objective";s:335:"There is some evidence that shows Matricaria chamomile (MC) plays an important role in ischemia-reperfusion. In the present study, a rat model of torsion/detorsion to investigate the effect of hydroalcoholic extract of MC on testis tissue damage was used. In adult rat testis, the oxidative stress (OS) induced by ischemia-reperfusion.";s:19:"MaterialsAndMethods";s:913...

2017
Megan J Reiniers Rowan F van Golen Sylvestre Bonnet Mans Broekgaarden Thomas M van Gulik Maarten R Egmond Michal Heger

Oxidative stress, a state in which intra- or extracellular oxidant production outweighs the antioxidative capacity, lies at the basis of many diseases. DCFH2-DA (2',7'-dichlorodihydrofluorescein diacetate) is the most widely used fluorogenic probe for the detection of general oxidative stress. However, the use of DCFH2-DA, as many other fluorogenic redox probes, is mainly confined to the detect...

2014
Omer Erkan Yapca Mehmet Ibrahim Turan Bunyamin Borekci Fatih Akcay Halis Suleyman

OBJECTIVES This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. MATERIALS AND METHODS Diabetic rats were divided into a...

Journal: :iranian journal of basic medical sciences 0
omer erkan yapca sorgun state hospital, obstetric and gynecology, yozgat, turkey mehmet ibrahim turan research and educational hospital, department of pediatrics, diyarbakir, turkey bunyamin borekci ataturk university, department of obstetrics and gynecology, erzurum, turkey fatih akcay ataturk university, department of biochemistry, erzurum, turkey halis suleyman recep tayyip erdogan university, department of pharmacology, rize, turkey

objective(s):this study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (i/r) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. it also examined the effects of the drugs aimed at preventing infertility that may result from i/r injury. materials and methods: diabetic rats were divided into ...

Hepatic ischemia-reperfusion (I/R) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. Mechanisms involved in I/R damage are very intricate and cover several aspects. Several factors are involved in I/R-induced damages; briefly, decrease in sinusoidal perfusion and ATP generatio...

Bunyamin Borekci, Fatih Akcay, Halis Suleyman, Mehmet Ibrahim Turan Omer Erkan Yapca

Objective(s):This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. Materials and Methods: Diabetic rats were divided into ...

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