Portulaca oleracea is a universal species with broad range of biological activities, including antioxidant and neuroprotective actions. The present study aimed to estimate the effect purslane ethanolic extract (PEE) aqueous (PAE) on depression model induced by reserpine. Methods: Seventy five male mice were divided into 5 groups (15 each). 1st group control (C), 2nd treated reserpine 0.1 mg/kg ...

In disturbed patients with mental illness of many kinds, the benefits of reserpine are well recognized, though in many cases the side-effects are so unpleasant as to outweigh the advantages (Hambling, 1957). Besides reserpine, other Rauwolfia alkaloids are active (Schneider, Plummer, Earl, and Gaunt, 1955); indeed the whole root has been used in India for centuries by Ayurvedic physicians under...

N.W. WEISBRODT, C.C. HUG, Jr., S.K. SCHMIEGE and P. BASS, Effects of nicotine and tyramine on contractile activity of the colon, European J. Pharmacol. 12 (1970) 310-319. Contractile activity of the descending colon of the anesthetized dog was monitored with strain gage force transducers. Nicotine and tyramine caused primarily a relaxation of the circular and longitudinal muscle. A secondary st...

It has been well established that the application of reserpine in vivo leads to a prolonged decrease in endogenous noradrenaline (NA) content and reduces the responses of various kinds of sympathetically inner vated organs to the nerve stimulation. However, there are few available reports about the action of reserpine in acute phase. In the present experiment, it was investigated in the isolate...

To compare findings in a hospital trial of hypotensive drugs with those in a general practice trial several patients with mild hypertension were studied at the same time in hospital and in general practice. They received bendrofluazide and potassium chloride or bendrofluazide, potassium chloride, and reserpine according to a double-blind crossover protocol, and blood biochemical values were stu...