1. a. Reserpine is a risk factor. Overall, the incidence of breast cancer is 10.47 per 100,000 women-years in reserpine users and 6.14 per 100,000 women-years in nonusers. Moreover, among the non-obese, the rate ratio is: 6.40/4.10 = 1.6. Looking in the non-obese women avoids potential confounding by obesity if it is a risk factor. b. Obesity is also a risk factor. The overall incidence rates f...

Fixed oil of O. basilicum was found to possess significant antiulcer activity against aspirin, indomethacin, alcohol, histamine, reserpine, serotonin and stress-induced ulceration in experimental animal models. Significant inhibition was also observed in aspirin-induced gastric ulceration and secretion in pylorus ligated rats. The lipoxygenase inhibiting, histamine antagonistic and antisecretor...

The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 - 3000mg/kg) inhibited ethanol-induced, indomethacin - induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the stand...

A syndrome of akinesia, rigidity and tremor can be induced in rats after administration of reserpinel' 2 . A technique giving access to the activity of single efferent axons and motor units without interfering with the induced motor phenomena was developed for an analysis of the muscle control in the reserpine syndrome2 . A decrease of y -fibre activity and an increase of a-fibre activity was d...

Vascular smooth muscle sensitivity to catecholamine-induced contraction is increased after catecholamine depletion by chemical sympathectomy and decreased after exogenous catecholamine administration. To investigate the role of the vascular o-adrenergic receptor in these alterations, we used the a-1 selective radioligand, (H)-WB-4101, [phenoxy-3-H(JV)]-(2-(2,6-dimethoxyphenoxyethyl)aminomethyl-...

Chronic administration of reserpine to rats increases, in sympathetic ganglia and adrenal medulla, the activity of tyrosine hydroxylase (EC 1.14.3.x), the enzyme catalyzing the rate-limiting step in the biosynthesis of catecholamines. Immunochemical titration of the enzyme in both adrenal gland and innervated superior cervical ganglia demonstrates that enhanced enzyme activity is entirely attri...

The potent antihypertensive drug reserpine inhibits the transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Reserpine acts by binding almost irreversibly to the vesicular amine transporter, and this interaction has been used both to study the mechanism of transport and to purify the protein responsible. Recent isolation of a cDNA for the rat chromaffin granule a...

Rats with desoxycorticosterone (DCA) -saline induced hypertension have been shown to exhibit increased susceptibility to experimental pyelonephritis (1, 2). These studies lend support to the hypothesis that various injuries, including nephrosclerosis, predispose to human pyelonephritis and that pyelonephritis is superimposed upon hypertensive disease more frequently than is usually suspected. O...