Influenza is a global public health threat, with seasonal and pandemic influenza resulting in substantial impact on health, the economy and society. The World Health Organization (WHO) has recently estimated that every year, 290 000 to 650 000 deaths are associated with respiratory diseases from seasonal influenza.1 This estimate takes into account findings from recent influenza respiratory mor...

Exchange of O(2) and CO(2) of plants with their environment is essential for metabolic processes such as photosynthesis and respiration. In some fruits such as pears, which are typically stored under a controlled atmosphere with reduced O(2) and increased CO(2) levels to extend their commercial storage life, anoxia may occur, eventually leading to physiological disorders. In this manuscript we ...

Mitochondrial dysfunction has been implicated in many neurological disorders that only develop or are much more severe in adults, yet no methodology exists that allows for medium-throughput functional mitochondrial analysis of brain sections from adult animals. We developed a technique for quantifying mitochondrial respiration in acutely isolated adult rat brain sections with the Seahorse XF An...

Although obesity and physical activity have been argued to predict back pain, these factors are also related to incontinence and breathing difficulties. Breathing and continence mechanisms may interfere with the physiology of spinal control, and may provide a link to back pain. The aim of this study was to establish the association between back pain and disorders of continence and respiration i...

Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to -Lactam Antibiotics Samira Dahesh,† Mary E. Hensler,† Nina M. Van Sorge, Robert E. Gertz, Jr., Stephanie Schrag, Victor Nizet, and Bernard W. Beall* Division of Pharmacology and Drug Discovery, Department of Pediatrics, and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California...

This article examines the impact of the introduction of ICD-10 on respiratory disease mortality statistics in England and Wales, specifically focussing on pneumonia, chronic lower respiratory diseases, and influenza. The main changes are highlighted and the article explains how figures can be adjusted to take account of these changes so that trends over time can be analysed. The number of death...