Abstract Hemophilia A is an X-linked bleeding disorder resulting in events due to insufficient levels of factor VIII (FVIII). The most significant complication the management hemophilia formation polyclonal neutralizing IgG (i.e., inhibitors) which impede FVIII procoagulant activity. In a (FVIII KO) murine model injected with multiple doses FVIII, FVIII-specific IgM were found persist despite e...

Normal serum contains a lymphocyte response depressive factor and this is more active against the lymphocytes of the blood from which the serum was obtained than against lymphocytes from a different normal blood. The suppressive factor is thus "tailor-made" to its own lymphocytes though cross-reactivity with other lymphocytes does occur. The significance of this is discussed. The suppressive fa...

Standard practice in response surface methodology performs factor screening and response surface exploration sequentially, using different designs. A novel approach is proposed to achieve the two objectives on the same experiment, based on one design. Running a uni-stage experiment has the advantages of saving experimentation time and run size. The approach is based on a two-stage analysis that...

Factor or conditional independence models based on copulas are proposed for multivariate discrete data such as item responses. The factor copula models have interpretations of latent maxima/minima (in comparison with latent means) and can lead to more probability in the joint upper or lower tail compared with factor models based on the discretized multivariate normal distribution (or multidimen...

background economic consequence analysis is vital for recognizing pipeline comprehensive risk analysis and emergency response planning. objectives the purpose of this study was to estimate economic loss due to fire and explosion in petrochemical feed and product pipelines. materials and methods the present study which performed on 47 pipelines of a petrochemical special zone, pertinent pipeline...

background and objective: vascular endothelial growth factor (vegf) and its receptors (vegf-r1 and r2) are major regulators of angiogenesis. this study was designed to assess serum levels of vegf and vegf-r1 and their prognostic significance in newly diagnosed childhood acute leukemia. materials and methods: for this purpose, vegf and vegf-r1 were determined using enzyme linked immuno-sorbant a...

the hypotensive effect of garlic has been well-documented in human subjects and animals. since endothelial activity regulates vascular reactivity in physiological and pathophysiological conditions, the aim of the present study was to investigate the effect of garlic on endothelium-dependent and independent relaxation of rat aorta for elucidation of mechanism of the garlic anti-hypertensive effe...