Upon ligand binding, epidermal growth factor (EGF) receptor (R) autophosphorylates on COOH-terminal tyrosines, generating docking sites for signaling partners that stimulate proliferation, restitution, and chemotaxis. Specificity for individual EGFR tyrosines in cellular responses has been hypothesized but not well documented. Here we tested the requirement for particular tyrosines, and associa...

Spatial heterogeneity of repolarization can provide a substrate for reentry to occur in myocardium. This heterogeneity may result from spatial differences in action potential duration (APD) restitution. The restitution portrait (RP) measures many aspects of rate-dependent restitution: the dynamic restitution curve (RC), S1-S2 RC, and short-term memory response. We used the RP to characterize ep...

The spatial variation in restitution properties in relation to varying stimulus site is poorly defined. This study aimed to investigate the effect of varying stimulus site on apicobasal and transmural activation time (AT), action potential duration (APD) and repolarization time (RT) during restitution studies in the intact human heart. Ten patients with structurally normal hearts, undergoing cl...

Small bowel epithelium is at the frontline of intestinal barrier function. Restitution is considered to be the major determinant of epithelial repair, because function recovers in parallel with restitution after acute injury. As such, studies of intact mucosa have largely been replaced by migration assays of cultured epithelia. These latter studies fail to account for the simultaneous roles pla...

Early epithelial restitution is an important repair modality in the gut mucosa and occurs as a consequence of epithelial cell migration. Canonical transient receptor potential-1 (TRPC1) functions as a store-operated Ca2+ channel (SOCs) in intestinal epithelial cells (IECs) and regulates intestinal restitution, but the exact upstream signals initiating TRPC1 activation after mucosal injury remai...

BASS, kz G. htitution of the action potential in cat papillary muscle. Am. J. Physiol. Z%(6) : 17 17-l 724. 1975.-Membrane recovery (electrical restitution) following an action potential (AP) was studied in isolated, electrically driven cat papillary muscle by interpolation of test extrasystoles at various delays in the interval between two AP’s (recorded with glass microelectrodes). Curves des...

Action potential duration (APD) restitution, which relates APD to the preceding diastolic interval (DI), is a useful tool for predicting the onset of abnormal cardiac rhythms. However, it is known that different pacing protocols lead to different APD restitution curves (RCs). This phenomenon, known as APD rate dependence, is a consequence of memory in the tissue. In addition to APD restitution,...

Egan, Laurence J., Ana de Lecea, Evan D. Lehrman, Gennett M. Myhre, Lars Eckmann, and Martin F. Kagnoff. Nuclear factorB activation promotes restitution of wounded intestinal epithelial monolayers. Am J Physiol Cell Physiol 285: C1028–C1035, 2003. First published June 25, 2003; 10.1152/ajpcell.00167.2003.—Epithelial restitution, the movement of wound-edge cells into an area of epithelial cell d...

BACKGROUND The mechanism by which structural barriers promote wave break and fibrillation is unclear. Conduction velocity (CV) restitution is an important determinant of wave break. Abnormal CV restitution is associated with ventricular fibrillation in patients with heart disease and arises preferentially in fibrotic myocardium. We hypothesize that tissue discontinuities imposed by structural b...

Struggles between current tenants and the heirs of former owners over property rights in post-socialist housing restitution Romania often unfold through kinship measurements. I use notion ‘boundary kin’—relatives who different situations may be considered as either near or distant—to capture role that measurements play these conflicts. Expanding ties to past, a large number persons are seeking ...