Muscular dystrophies comprise a heterogeneous cluster of inherited muscle degenera‐ tive disorders with the common feature of progressive muscle weakness. These represent good candidates for treatment with gene-based therapies. Progress in gene transfer technologies has raised hopes for successful therapeutic restoration of mutated genes such as dystrophin in Duchenne muscular dystrophy. Delive...

Inpainting is the technique of modifying an image in an imperceptible form, is a very old fine art itself. The goals and applications of inpainting are frequent from the restoration of damaged paintings and image photographs to the removal or replacement of selected objects. Image Inpainting is the ability of filling in misplaced data in an image. The principle of inpainting is to restructure m...

BACKGROUND In this study, we tested the hypothesis that 17beta-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase in serum testosterone after long-term (6 weeks) castration constituted a basis for testing the hypothesis that a spontaneous increase in serum testosterone or androstenedi...

All ceramic fixed partial dentures (FPD)s exhibit enhanced biocompatibility and esthetics as compared to metal-ceramic restorations. However, framework fractures are frequently reported especially when the connector dimensions are inadequate to withstand the high tensile stresses. The repair of the failed connector would be desirable rather than the complete removal and renewal since the latter...

Rationals for total disc replacement Dynamic reconstruction of a degenerative “functional spinal unit” (FSU) is a rapidly growing field in spinal surgery. So far anterior cervical discectomy and fusion (ACDF), first described by Smith and Robinson and by Cloward in the 1950s, is the most common surgical procedure proven successful in the treatment of symptoms caused by cervical degenerative dis...

The successful restoration of visual function with recombinant adeno-associated virus (rAAV)-mediated gene replacement therapy in animals and humans with an inherited disease of the retinal pigment epithelium has ushered in a new era of retinal therapeutics. For many retinal disorders, however, targeting of therapeutic vectors to mutant rods and/or cones will be required. In this study, the pri...

Image fiber bundles are employed in fusion experiments and other high radiation environments where they are used to transmit an image from an unprotected objective lens to a radiation shielded camera. Due to their exposure to neutron and gamma radiation the transmission of these expensive image fiber bundles can rapidly degrade, especially at the shorter visible wavelengths, and require costly ...

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease with unmet medical need. The disease is caused by mutations that disrupt the open reading frame of the dystrophin protein that is required to maintain muscle fiber stability during contraction. Lacking dystrophin patients' muscle fibers are continuously damaged eventually leading to replacement of muscle tissue by fibrotic and...

Clinical trials have identified secondary caries and bulk fracture as the main causes for composite restoration failure. As a measure to avoid frequent reinterventions for restoration replacement, composites with some sort of defense mechanism against biofilm formation and demineralization, as well as materials with lower susceptibility to crack propagation are necessary. Also, the restorative ...

LH/hCG receptors were disrupted by gene targeting in embryonic stem cells. The disruption resulted in infertility in both sexes. The gonads contained no receptor mRNA or receptor protein. Serum LH levels were greatly elevated, and FSH levels were moderately elevated in both sexes; estradiol and progesterone levels decreased but were not totally suppressed in females; testosterone levels were dr...