Andrew Maslow MD Department of Anesthesiology Rhode Island Hospital, Providence Rhode Island Introduction Cardiomyopathy is generally defined as a “disease of the myocardium associated with cardiac dysfunction”. 1 Primary cardiomyopathies are divided into three major classifications: a) dilated cardiomyopathy (DCM), b) hypertrophic cardiomyopathy (HCM), and c) restrictive (or infiltrative) card...

AIMS To identify carriers and non-carriers of the mutant transthyretin methionine 111 linked familial amyloid disease, to detect early signs of the restrictive cardiomyopathy and other clinical manifestations characteristic of this inheritable disease. METHODS AND RESULTS Out of 125 living family members 99 were available for clinical, echocardiographic and genetic examination. Twenty-five fa...