Fragile X syndrome, the most common heritable form of mental retardation, is caused by silencing of the FMR1 (fragile X mental retardation-1 gene). The protein product of this gene, FMRP (fragile X mental retardation protein), is thought to be involved in the translational regulation of mRNAs important for learning and memory. In mammals, there are two homologues of FMRP, namely FXR1P (fragile ...

A person with moderate mental retardation would, in a western country, be "diagnosed" early on in life. Consequently, such a child is likely to be sent for special education. Given the high level of job requirements, such a person is unlikely to be employed in the open market later in life. Mental retardation is one of the most frequent disabilities in most studies, mental retardation is found ...

Down syndrome (DS) is a chromosomal disorder associated with short stature and psychomotor delay. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are of interest in DS as the pronounced growth retardation coincides in time when GH becomes essential for growth. Simultaneously mean intelligence quotient (IQ) decreases

[1] A sensitivity analysis reveals that large uncertainty exists in estimates of solute retardation factor R made from sorption push-pull tests. A simplified push-pull data interpretation method for estimating instantaneous linear sorption in confined aquifers is developed. The new method is less restrictive in its application than the conventional method that uses an approximate analytical sol...

This small book is the first of a series of occasional papers which are to be published under the auspices of the Institute for Research into Mental Retardation, and its author is the chairman of the Institute's Research Committee. In the preface, it is said to be aimed at an intelligent lay audience and it is suggested that 'it will be read with interest and profit by workers in the field of m...

Background and aims The relationship between negative symptoms and cognition in schizophrenia is not clear, inconsistent findings have been reported by multiple authors and meta analyses. The aim of this study was to investigate the relationship between cognition and primary negative symptoms. Methods 67 outpatients diagnosed with schizophrenia were evaluated using PANSS and the NSA-16 scale....

BACKGROUND Although X-linked mental retardation (XLMR) affects 2%-3% of the human population, little is known about the underlying molecular mechanisms. Recent interest in this topic led to the identification of several genes for which mutations result in the disturbance of cognitive development. RESULTS We identified a novel gene that is interrupted by an inv(X)(p21.1;q22) in a male patient ...

In a recent paper, we have shown that the flattening of galactic rotation curves can be explained by retardation. However, this will rely on temporal change mass. our previous work, kept only second order terms retardation time in analysis, while higher Taylor expansion where not considered. Here consider analysis to all orders and show indeed suffice, neglected.

mental retardation (mr) is one of the most frequently found major genetic disorders around the world, affecting 1-3% of the people in the general population. the recent advancement in molecular biology and cytogenetic study has made possible the identification of new genes for a variety of genetic disorders including autosomal recessive mr. recessive genetic disorders are common in pakistan due...