The objective of the present study was to conduct the first systematic review and meta-analysis of prospective studies investigating the associations between total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels and the risk of breast cancer. Relevant studies were identified in PubMed (up to January 2014). Inclusion criteria were original peer-reviewed publications ...

The author critically reviews a randomised controlled trial by homeopathy for chronic headache and an observational follow-up studyof the same patient cohort.The results showed no di¡erence between homeopathy and placebo. The author believes that theseresultswere a‘falsenegative’due to inadequatehomeopathic treatment, particularly relating to the duration of symptoms and handling of homeopathic...

OBJECTIVE To review the evidence on the association between fruit and vegetable (F&V) consumption and risk of chronic disease, and to assess trends in the prevalence of low F&V consumption. DESIGN Systematic review and cross-sectional analyses of a Mediterranean cohort. SETTING The Seguimiento University of Navarra (SUN) project (Spanish dynamic cohort of graduates). SUBJECTS A systematic...

Response We are able to compare our spectrum of travellers to the WTO travel statistics for Switzerland and to European airport studies. From there, we know that travellers to North Africa, the Middle East and the Caribbean region are underrepresented as we have highlighted in the DISCUSSION section. In addition, we have specified the manuscript title to clearly state that only travellers to re...

PURPOSE The Accreditation Council for Graduate Medical Education (ACGME) states that "residents should participate in scholarly activity." However, there is little guidance for effectively integrating scholarly activity into residency. This study was conducted to understand how pediatric residency programs meet ACGME requirements and to identify characteristics of successful programs. METHOD ...

Wheezing is one of the most frequent complaints that lead to the use of medical resources in younger children. Generally, wheezing is caused by bronchiolitis and resolves spontaneously without recurrence, but sometimes, wheezing can progress into asthma. Early data on the natural history of childhood wheezing was mostly obtained from retrospective reviews of medical records or from questionnair...

tial multicentre ones not funded by industry, which together have been cited over 800 times in the literature already, that have confirmed that there are indeed no special advantages of atypical antipsychotics in the treatment of schizophrenia and, compared with conventional anti-psychotic drugs, they are not costeffective. I deliberately put the word ‘‘confirmed’’ in italics because the wordin...

BACKGROUND Many research participants are misinformed about research terms, procedures, and goals; however, no validated instruments exist to assess individual's comprehension of health-related research information. We propose research literacy as a concept that incorporates understanding about the purpose and nature of research. OBJECTIVES We developed the Research and Knowledge Scale (RaKS)...