The bifunctional protein RGS14 is both a GTPase activating protein (GAP) for GiR and GoR and a guanine nucleotide dissociation inhibitor (GDI) for GiR. This GDI activity is isolated to a region of the protein distinct from the RGS domain that contains an additional G protein-binding domain (RBD/ GL). Here, we report that RGS14 missing its RGS domain (R14-RBD/GL) binds directly to Go and Gi to m...

Objective. To describe a technique that assists in the surgical management of recurrent local regional well-differentiated thyroid cancer (WDTC). Study Design. Case series with chart review. Setting. Two academic health centers from 2001 to 2009. Subjects and Methods. Patients operated upon by the senior surgeon (BCS) for recurrent WDTC. Results. Thirteen patients with recurrent WDTC were opera...

gand-inducible transcription factors. They include the receptor proteins for steroids, thyroid hormone, vitamin D, and retinoids. Steroid hormone receptors are structurally related and composed of six major functional domains. Domain A/B in the NH2-terminal region of the protein is the constitutive activation 1 (AF-1). Domain C, the DNA-binding domain, is arranged in two zinc-stabilized DNA-bin...

Fourteen statistics novices were asked to solve three statistics word problems under standard (SGS) or reduced (RGS) goal specificity. Later, they were asked to solve both structurally identical and structurally different transfer problems, and their structural knowledge of the domain was assessed. Results indicate that participants in the RGS condition performed better on the structurally diff...

Here we present a virtual reality system developed for the rehabilitation of motor deficits following stroke. A virtual reality augmented feedback system or the Rehabilitation Gaming System (RGS), presents the patient with a training scenario that is designed to promote the rehabilitation of the upper extremities. RGS allows rapid and online diagnostics of the patient’s capabilities and the dyn...

BACKGROUND Gene expression analysis is an essential part of biological and medical investigations. Quantitative real-time PCR (qPCR) is characterized with excellent sensitivity, dynamic range, reproducibility and is still regarded to be the gold standard for quantifying transcripts abundance. Parallelization of qPCR such as by microfluidic Taqman Fluidigm Biomark Platform enables evaluation of ...

The regulator of G protein signaling (RGS) proteins are a family of guanosine triphosphatase (GTPase)-accelerating proteins. We have discovered a novel function for RGS2 in the control of protein synthesis. RGS2 was found to bind to eIF2Bepsilon (eukaryotic initiation factor 2B epsilon subunit) and inhibit the translation of messenger RNA (mRNA) into new protein. This effect was not observed fo...

Regulators of G protein signaling (RGS), which act as GTPase activators, are a family of cytosolic proteins emerging rapidly as an important means of controlling G protein–mediated cell signals. The importance of RGS action has been verified in vitro for various kinds of cell function. Their in situ modes of action in intact cells are, however, poorly understood. Here we show that an increase i...

Regulators of G protein signaling (RGS), which act as GTPase activators, are a family of cytosolic proteins emerging rapidly as an important means of controlling G protein-mediated cell signals. The importance of RGS action has been verified in vitro for various kinds of cell function. Their in situ modes of action in intact cells are, however, poorly understood. Here we show that an increase i...