نتایج جستجو برای: rheumatoid arthritis ra
تعداد نتایج: 107760 فیلتر نتایج به سال:
BACKGROUND Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in Rheumatoid Arthritis. The Multidrug resistance Related Protein and Multi Drug Resistance protein 1, also called P-glycoprotein-170 transporters can alter the intracellular conc...
Methotrexate (MTX) in low doses is used in the therapy of rheumatoid arthritis (RA). The aim of many studies is to identify factors predicting the outcome of treatment with methotrexate in rheumatoid arthritis. The action of MTX in RA is associated with the inhibition of inflammatory mediators synthesis. AIF-1 is a cytokine playing a role in chronic inflammatory processes. The levels of AIF-1 w...
Gout is a disorder of purine metabolism characterised by hyperuricemia, deposition of monosodium urate monohydrate crystals in joints and periarticular tissues with recurrent attack of acute synovitis. Rheumatoid arthritis (RA) and gout are relatively common disease, but their coexistence is extremely rare. We report a case of 69yrs old female on presentation likely to have rheumatoid arthritis...
آرتریت روماتوئید rheumatoid arthritis,(ra) یک بیماری خود ایمن است که یکی از معیارهای تشخیصی آن وجود فاکتور روماتوئید ( rheumatoid factor,rf ) در سرم بیماران می باشد. مطالعات نشان داده اند که بین بیماران آرتریت روماتوئید rf+ و rf- از نظر تظاهرات بافت شناسی ( histologic ) اختلافاتی وجود دارد. در این مطالعه میزان (crp) c-reactive protein و ایزوتیپهای iga rf و igm rf در 45 بیمار مبتلا به ra مورد سن...
C ompared with monoarticular arthritis, polyarticular arthritis may yield an initially narrower differential diagnosis that focuses on systemic inflammatory conditions, such as rheumatoid arthritis (RA). Approximately 15% to 30% of septic arthritis is polyarticular, of which about 45% is associated with underlying RA.1,2 Regardless of the number of joints involved, septic (infectious) arthritis...
Synovial leukocyte apoptosis is inhibited in established rheumatoid arthritis (RA). In contrast, high levels of leukocyte apoptosis are seen in self-limiting crystal arthritis. The phase in the development of RA at which the inhibition of leukocyte apoptosis is first apparent, and the relationship between leukocyte apoptosis in early RA and other early arthritides, has not been defined. We meas...
introduction: the activity of hypothalamus-pituitary-adrenal (hpa) axis is increased following inflammation due to its closed relation with immune system. this axis indicates an increased secretion of acth, and corticosterone during acute inflammation while little is known about its activity during chronic inflammation such as rheumatoid arthritis (ra). in this study we measured the products of...
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II molecules to study the interaction between the DR and DQ molecules and define the immunologic mechanisms in rheumatoid arthritis. Using collagen-induced arthritis (CIA) as an experimental mo...
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