Purpose: Coronary angiography can cause post-procedural pain, and limited flexibility in the hips and knees may contribute to this discomfort. Patients with restricted hip and knee flexibility may experience increased stress. This study was designed to assess the flexibility of the hip and knee and its relationship with pain experienced after femoral angiography. Methods: This cross-sectional ...

Within blood vessels, endothelial cellâ€"cell and cellâ€"matrix adhesions are crucial to preserve barrier function, and these adhesions are tightly controlled during vascular development, angiogenesis, and transendothelial migration of inflammatory cells. Endothelial cellular signaling that occurs via the family of Rho GTPases coordinates these cell adhesion structures through cytoskeletal remo...

Wnt/Frizzled (Fz) signaling controls cell polarity/movements during vertebrate gastrulation via incompletely defined mechanisms. We demonstrated previously that Wnt/Fz activation of Rho, a GTPase and regulator of cytoskeletal architecture, is essential for vertebrate gastrulation. Here we report that in mammalian cells and Xenopus embryos, Wnt/Fz signaling coactivates Rho and Rac, another GTPas...

multiple sclerosis (ms) is an inflammatory disease of central nervous system (cns) and sexual dysfunction (sd) is one of the most common disabilities of ms women. the aim of this study was to determine sexual function of women with ms (multiple sclerosis). one hundred definite ms patients ms patients and fifty age-matched healthy controls were enrolled. demographic data (sex, age), duration of ...

Abstract Background Little is known about coronary microvascular function of patients with low-flow low-gradient aortic stenosis (LFLGAS). We hypothesized that LFLGAS associated more severe dysfunction (CMD) compared normal-flow high-gradient (NFHGAS) and CMD related to reduced cardiac efficiency. Purpose To perform a prospective invasive assessment in undergoing TAVI compare it NFHGAS. Moreove...

Significant impairment in endothelial-derived nitric oxide is present in the diabetic corpus cavernosum. RhoA/Rho-kinase may suppress endothelial nitric oxide synthase (eNOS). Here, we tested the hypothesis that RhoA/Rho-kinase contributes to diabetes-related erectile dysfunction and down-regulation of eNOS in the streptozotocin (STZ)-diabetic rat penis. Colocalization of Rho-kinase and eNOS pr...