Background The MMEx Diabetes Foot risk calculator was designed in response to the WA Department of Health’s High Risk Foot Model of Care to improve the systematic approach to screening and treatment for high risk foot complications and the 2011 National Health and Medical Research Council’s (NHMRC) National Evidence-Based Guideline on Prevention, Identification and Management of Foot Complicati...

Although sinus bradycardia is a common abnormality seen in medical reports, the proper evaluation of sinus bradycardia is poorly understood by physicians. Recent data from heart rate epidemiologic and cohort studies has emerged regarding the risk stratification of sinus bradycardia, which may help insurers better underwrite this abnormality. In this review, an operational age-related heart rate...

The purpose of the present review is to describe how we improve the model for risk stratification of transplant outcomes in kidney transplantation by incorporating the novel insights of donor-specific anti-HLA antibody (DSA) characteristics. The detection of anti-HLA DSA is widely used for the assessment of pre- and posttransplant risks of rejection and allograft loss; however, not all anti-HLA...

BACKGROUND Administrative databases and cancer registries are frequently used to conduct population-based research, but often lack clinical data necessary for risk stratification. Our objective was to determine the criterion validity of a risk-stratification algorithm based on treatment characteristics available from a pediatric cancer registry as a proxy for disease risk, by comparing it to tr...

The aim of this meta-analysis was to evaluate the association between cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene rs1063192 polymorphism and glaucoma risk. We searched the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 14 case-control studies involving 11,316 cases and ...

The stratification of patients with acute lymphoblastic leukemia (ALL) into treatment risk groups based on quantification of minimal residual disease (MRD) after induction therapy is now well accepted but the relapse rate of about 20% in intermediate risk patients remains a challenge. The purpose of this study was to further improve stratification by MRD measurement at an earlier stage. MRD was...

OBJECTIVE To improve on the existing risk-stratification systems for prostate cancer. PATIENTS AND METHODS This was a retrospective investigation including 2 248 patients undergoing dose-escalated external beam radiotherapy (EBRT) at a single institution. We separated National Comprehensive Cancer Network (NCCN) intermediate-risk prostate cancer into 'favourable' and 'unfavourable' groups bas...

BACKGROUND Given the increasing worldwide incidence of diabetes, methods to assess diabetes risk which would identify those at highest risk are needed. We compared two risk-stratification approaches for incident type 2 diabetes mellitus (T2DM); factors of metabolic syndrome (MetS) and a previously developed diabetes risk score, PreDx® Diabetes Risk Score (DRS). DRS assesses 5 yr risk of inciden...

speculate that a positive marker may indicate the need for systemic chemotherapy or radiotherapy. Such data promise the potential for preoperative tissue/gene-based risk stratification, which most certainly will have some cut-off for risk/benefit for either neoadjuvant therapy or surgery. If EUSguided FNA-based molecular and gene expression can be used to risk-stratify patients, this would be a...