The ability of peptide-modified gold nanoparticles to target the nucleus of HepG2 cells was explored. Five peptide/nanoparticle complexes were investigated, particles modified with (1) the nuclear localization signal (NLS) from the SV 40 virus; (2) the adenovirus NLS; (3) the adenovirus receptor-mediated endocytosis (RME) peptide; (4) one long peptide containing the adenovirus RME and NLS; and ...

Rapid maxillary expansion (RME) is a widely used practice in orthodontics. Scientific evidence shows that RME can be helpful in modifying the breathing pattern in mouth-breathing patients. In order to promote the restoration of physiological breathing we have developed a rehabilitation program associated with RME in children. The aim of the study was a literature review and a model of orofacial...

Objective: The aim of this study was to evaluate by Cone-Beam Computed Tomography (CBCT) transversal responses, immediately and after the retention period, to rapid maxillary expansion (RME), in Class II malocclusion patients. Methods: Seventeen children (mean initial age of 10.36 years), with Class II malocclusion and skeletal constricted maxilla, underwent Haas ́ protocol for RME. CBCT scans w...

OBJECTIVES The aim of this study was to analyze the displacement pattern and stress distribution during surgically assisted rapid maxillary expansion (RME) with three different types of RME devices by constructing a finite element model. MATERIALS AND METHODS A finite element model is constructed from the computerized tomography scans. According to the type of RME device, 3 groups were simula...

The purpose of this study was to investigate the stability of the medial aspects of the rugae in patients where rapid maxillary expansion (RME) was performed in addition to fixed appliance therapy. Nineteen subjects that met the inclusion criteria for each group were randomly selected from the archive of one orthodontist office. The RME/fixed appliances group consisted of 8 males and 11 females...

Endocytic motifs in the carboxyl terminus of cystic fibrosis transmembrane conductance regulator (CFTR) direct internalization from the plasma membrane by clathrin-mediated endocytosis. However, the fate of such internalized CFTR has remained unknown. Internalized membrane proteins can be either targeted for degradation or recycled back to the plasma membrane. Using cell surface biotinylation a...

OBJECTIVE To assess the scientific evidence that rapid maxillary expansion (RME) causes Adverse Effects on the midpalatal suture, vertical dimension, dental and periodontal structures in growing subjects. MATERIALS AND METHODS Electronic databases were searched for articles dated through December 2011. The quality of the studies was ranked on a 13-point scale in which 1 was the low end of the...

Bonded maxillary expansion appliances have been suggested to control increases in the vertical dimension of the face after rapid maxillary expansion (RME). However, there is still no consensus in the literature about its real skeletal effects. The purpose of this prospective study was to evaluate, longitudinally, the vertical and sagittal cephalometric alterations after RME performed with bonde...

Impaired respiratory muscle endurance (RME) could reduce exercise tolerance and contribute to ventilatory failure. The aim of the present study was to develop a clinically-feasible method to measure RME using negative-pressure inspiratory-threshold loading. It was hypothesized that endurance time (tlim) could be predicted by normalizing oesophageal pressure-time product (PTP) per total breath c...

OBJECTIVE To assess skeletal and dental changes immediately after rapid maxillary expansion (RME) in Class II Division 1 malocclusion patients and after a retention period, using cone beam computed tomography (CBCT) imaging. METHODS Seventeen children with Class II, Division 1 malocclusion and maxillary skeletal transverse deficiency underwent RME following the Haas protocol. CBCT were taken ...