To quantitatively understand the events in the human liver, we modeled a hepatic disposition of bosentan and its three known metabolites (Ro 48-5033, Ro 47-8634, and Ro 64-1056) in sandwichcultured human hepatocytes based on the known metabolic pathway. In addition, the hepatotoxicity of Ro 47-8634 and Ro 64-1056 was investigated because bosentan is well known as a hepatotoxic drug. A model ill...

OBJECTIVE To assess the prevalence of anti-Ro/SSA in RA and to analyse clinical and serological features of anti-Ro/SSA positive patients with RA. METHODS 195 consecutive patients affected by RA were studied by counterimmunoelectrophoresis and ELISA for the detection of anti-Ro/SSA antibodies. Anti-Ro were found in 12 patients, with a prevalence of 6%. These 12 patients were pooled with other...

BACKGROUND Mathematical modelling of infectious disease is increasingly used to help guide public health policy. As directly transmitted infections, such as influenza and tuberculosis, require contact between individuals, knowledge about contact patterns is a necessary pre-requisite of accurate model predictions. Of particular interest is the potential impact of school closure as a means of con...

This paper projects the future of knowledge economy (KE) in SSA and MENA countries using the four components of the World Bank’s Knowledge Economy Index (KEI): economic incentive, education, ICTs and innovation. The empirical evidence provides the speeds of integration as well as the time necessary to achieve full integration. Findings broadly indicate SSA and MENA countries with low levels in ...

Reverse Osmosis (RO) is an efficient process for the removal of ionic and organic pollutants from wastewater. However, flux decline and rejection deterioration due to concentration polarization and membrane fouling hinders the application of RO technology. Rotating RO takes advantage of high shear and the Taylor vortex instability to reduce the flux decline related to concentration polarization...

measurement of bose-einstein correlations in the production of like-signed pion pairs has been made with the amy detector at tristan. an event sample of 10120 hadronic events with ranging between 50 to 61 gev was used. these measurements indicate a strength of the enhancement of ? = 0.61m.07, with a typical correlation size of ro = 1.16±.08 fm. this value of ? is consistent with measurements at...

In this study, the GPS radio occultation (RO) data from the Challenging Minisatellite Payload (CHAMP) and Satellite de Aplicaciones Cientificas-C (SAC-C) missions are assimilated. An updated version of the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5) four-dimensional variational data assimilation system (4DVAR) is used to assess t...