background: rheumatoid arthritis (ra) is the most common chronic inflammatory erosive joint disease with the worldwide distribution of approximately 0.5-1%. molecular methods can be very sensitive in the early stage diagnosis of the disease and therefore prevention the late complications and disabilities. etiology of ra, an autoimmune disease, is not exactly known but immunologic and genetic fa...

results two bacterial types, st208, and st218, were identified in all 140 samples. the st208 mainly came from icu and department of respiratory medicine, while st218 from department of plastic surgery; 70.21% of st208 and 84.78% of st218 were carbapenem-resistant acinetobacter baumannii (crab) and carbapenem-susceptible acinetobacter baumannii (csab), respectively. multidrug-resistance genes in...

the first step in mining activities is rock excavation in both mine development and production. constant pressure for cost reduction and creating an improved/safe work environment for personnel has naturally resulted in increased use of mechanical excavation systems in many mining operations. also, mechanical excavation and mining is more compatible with automation, meaning possibility of reduc...

the most important factor in donor-recipient matching for hematopoietic stem cell transplantation is their hla typing. for many patients, we can not find a full-matched donor. in high risk patients, one locus  mismatched related donors are suitable alternatives. (1, 2) since the matching of patients and their siblings usually is based on low resolution hla typing, the matching of one locus mism...

The PCR amplification of STR loci typically produces a minor byproduct called minus stutter (or plus stutter) that is one repeat unit shorter longer) than the original product. These stutters cause some problems affect result typing and complicate when comparing results typing. It necessary to remove in forensic Minus filtered out automatically by setting analysis software. On other hand, at mo...

Despite evidence that weathering plays a role in forming intertidal, estuarine, and fluvial rock platforms, many publications uncritically refer to “wave-cut” or “stream-cut” rock platforms. The alternative explanations of chemical weathering and physical water erosion of rock platforms have been debated since 1839. Our new approach to this long-standing problem introduces data from fluvial as ...

Peroxisome proliferator-activated receptor-γ (PPARγ) and Rho-kinase (ROCK) regulate smooth muscle cell (SMC) proliferation and contribute to vascular remodeling in adult pulmonary hypertension. Whether these pathways interact to contribute to the development of vascular remodeling in persistent pulmonary hypertension of the newborn (PPHN) remains unknown. We hypothesized that ROCK-PPARγ interac...

Rock physics modeling aims to provide a link between rock properties, such as porosity, lithology, and fluid saturation, and elastic attributes, such as velocities or impedances. These models are then used in quantitative seismic interpretation and reservoir characterization. However, most of the geophysical measurements are uncertain; therefore, rock physics equations must be combined with mat...

Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I-deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I(-/-) mice died soon after birth as a resul...