BACKGROUND Most patients with moderate and severe chronic obstructive pulmonary disease (COPD) receive long-acting bronchodilators (LABA) for symptom control. It is, however, unclear if and what drug treatments should be added to LABAs to reduce exacerbations, which is an important goal of COPD management. Since current guidelines cannot make strong recommendations yet, our aim was to determine...

We present an experimental investigation of the 60 GHz optical carrier suppressed radio over fiber systems with less than 5 dB carrier suppression. As a case study, the 60 GHz RoF signal is generated using a 12.5 Gb/s commercially available Mach-Zehnder modulator biased at its minimum point. We report on error free transmission over 20 km of standard single mode fiber and 1 m of wireless distan...

Small molecule phosphodiesterase (PDE) 4 inhibitors have long been known to show therapeutic benefit in various preclinical models of psychiatric and neurologic diseases because of their ability to elevate cAMP in various cell types of the central nervous system. Despite the registration of the first PDE4 inhibitor, roflumilast, for the treatment of chronic obstructive pulmonary disease, the th...

This investigation demonstrates the generation of OFDM-RoF signal using frequency doubling technique for the first time, to the author's best knowledge. The 4-Gb/s OFDM signal using 16-QAM format modulated on each subcarrier at a center frequency of 19GHz is experimentally demonstrated. Benchmarked against the OOK format, the 16-QAM OFDM format has the higher spectral efficiency with a sensitiv...

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is projected to be the third by 2020. COPD is characterized by chronic airflow limitation caused by airway inflammation and parenchymal destruction that is usually progressive. Inhaled bronchodilators continue to be the mainstay of the current management of COPD. Safety and efficacy data of the recen...

Creams and lotions use emulsifiers to create a physically stable vehicle for topically applied dosage forms. The minimum temperature required an anionic emulsifier form micelles, which can cause lipid extraction from skin result in irritation, is known as the Krafft (TK). A cream or lotion formulated with having TK above safe water exposure temperatures (approximately 50°C) cannot irritate due ...

Targeting type 4 phosphodiesterase (PDE4) for treatment of COPD has multilevel benefits to patients by reducing inflammation, relieving bronchoconstriction, and improving pulmonary circulation. The isoenzyme-specific narrow spectrum PDE4 inhibitors such as cilomilast and roflumilast may have limited clinical efficacy in managing severe and very severe COPD. Development of dual therapy by combin...